Abstract: SA-OR82
Contemporary Infant and Neonatal Dialysis (COINED) Study: Practice Patterns and Outcomes
Session Information
- Pediatric Nephrology: Clinical and Genetic Studies
November 04, 2023 | Location: Room 105, Pennsylvania Convention Center
Abstract Time: 05:06 PM - 05:15 PM
Category: Pediatric Nephrology
- 1900 Pediatric Nephrology
Authors
- Muff-Luett, Melissa A., University of Nebraska Medical Center, Omaha, Nebraska, United States
- Webb, Tennille N., University of Alabama at Birmingham, Birmingham, Alabama, United States
- Pottanat, Neha Dhingra, Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana, United States
- Starr, Michelle C., Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana, United States
- Thevarajah, Tamara, University of Nebraska Medical Center, Omaha, Nebraska, United States
- Carter, Caitlin E., University of California San Diego, Rady Children's Hospital, San Diego, California, United States
- Hyatt, Dylan Michael, University of California San Diego, Rady Children's Hospital, San Diego, California, United States
- Alhamoud, Issa, The University of Iowa Stead Family Children's Hospital, Iowa City, Iowa, United States
- Lande, Marc, University of Rochester Medical Center, Rochester, New York, United States
- Richardson, Kelsey L., Oregon Health & Science University, Portland, Oregon, United States
- Piburn, Kim H., The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States
- Kim, Hannah, Penn State College of Medicine, Hershey, Pennsylvania, United States
- Crawford, Brendan, Arkansas Children's Hospital, Little Rock, Arkansas, United States
- Ciccia, Eileen Anna, Washington University in St Louis School of Medicine, St Louis, Missouri, United States
- Villegas, Leonela A., Connecticut Children's Medical Center, Hartford, Connecticut, United States
- Nelson-Taylor, Sarah K., Children's Hospital of Colorado, Aurora, Colorado, United States
- High, Robin, University of Nebraska Medical Center, Omaha, Nebraska, United States
- Sanderson, Keia, University of North Carolina Kidney Center, Chapel Hill, North Carolina, United States
Background
Neonatal dialysis is technically challenging and rare. Prior neonatal dialysis research is primarily limited to medical claims/coding data. There are critical knowledge gaps specific to neonatal dialysis. Our objective was to describe contemporary neonatal dialysis demographics, access, modalities, complications, and outcomes.
Methods
This is a preliminary report from a multicenter retrospective cohort study of 14 centers in the Pediatric Nephrology Research Consortium. Neonates initiated on dialysis within the first 30 post-natal days between June 2017-May 2022 were enrolled. Neonates with a dialysis catheter placed post-cardiac surgery for fluid management without kidney dysfunction were excluded. Data were collected until initial hospital transfer/discharge.
Results
183 neonates on dialysis were enrolled. 58% were diagnosed with acute kidney injury (AKI) and 30% with end-stage kidney disease (ESKD). The majority received some form of continuous kidney replacement therapy (CKRT) (71%). 25% experienced a change in dialysis modality, 52% died before hospital discharge, and 19% remained on dialysis at discharge/transfer on dialysis.
Conclusion
In this multicenter, cohort, a larger number of neonates received CKRT, many neonates changed dialysis modalities prior to discharge/transfer, and mortality rates are far greater than previously reported. Future research to inform development of evidence-based guidelines is needed to improve neonatal dialysis management and outcomes.
Funding
- Private Foundation Support