Abstract: TH-PO882
Ongoing Sex Disparities in Living Kidney Transplantation: A UNOS Analysis
Session Information
- Transplantation: Donation and Access
November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 2102 Transplantation: Clinical
Authors
- Cabezas, Fausto Ricardo, SUNY Downstate Health Sciences University, New York City, New York, United States
- Sasidharan, Sandeep Raja, SUNY Downstate Health Sciences University, New York City, New York, United States
- Abushawer, Mohammad Waleed, SUNY Downstate Health Sciences University, New York City, New York, United States
- Jatoi, Tahir Ahmed, SUNY Downstate Health Sciences University, New York City, New York, United States
- Salifu, Moro O., SUNY Downstate Health Sciences University, New York City, New York, United States
- Gruessner, Angelika C., SUNY Downstate Health Sciences University, New York City, New York, United States
- Saggi, Subodh J., SUNY Downstate Health Sciences University, New York City, New York, United States
Group or Team Name
- SUNY Downstate Nephrology Division.
Background
In the United States, the prevalence of chronic kidney disease (CKD) is higher in females (16.2%) than in males (13.4%). Studies in Asia and Mexico have shown that females comprised 62% to 69% donors and were LKDT recipients in only 20% of cases. Disparities are not fully explained by socio-cultural or biological factors. Outdated U.S. data showed a lower rate of LDKT in females. We aim to explore current trend of LDKT in the US.
Methods
We queried the UNOS database for all adult primary single organ LDKTs from 2011 to 2022. We excluded deceased donor recipients which has been previously described. Comprehensive univariate and multivariate analyses were performed to describe changes and risk factors.
Results
There were 60,865 LDKTs, 36% were female recipients and 63.5% were donors (Table 1). The likelihood to receive a LDKTA decreased with increasing age. Black females were more likely to be donorsreceive a LD KTA when compared to white females (OR 1.4 [1.3-1.5] <0.001). Female donors recipients were less likely to be biologically related to male recipients to receive a nonbiologically related KTA (OR 0.89 [0.86-0.93] <0.001). Furthermore, female recipients were longer on the transplant waiting list and were more likely to have a higher a cPRA (OR 6.2 [6.2-7.3] <0.001). Female to Male donors accounted for 40.6% of donors, this trend remained stable throughout the study period.
Conclusion
Females are more likely to be donors than LDKTA recipients and face longer times in the transplant waiting list. Black females were more likely to be donors and less likely to be recipients when compared to white females. The sex disparities in KT listing and LKDT remains. However, socio-cultural factors, as well as biological factors influencing such disparities are yet to be elucidated. Data informed policy is warranted to bridge the sex disparities in LKDT.