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Abstract: FR-PO815

Exercise Has Mode-Specific Effects on Musculoskeletal Health in a Rat Model of CKD-MBD

Session Information

Category: Health Maintenance, Nutrition, and Metabolism

  • 1500 Health Maintenance, Nutrition, and Metabolism

Authors

  • Avin, Keith G., Indiana University Purdue University Indianapolis, Indianapolis, Indiana, United States
  • Troutman, Ashley Danielle, Indiana University Purdue University Indianapolis, Indianapolis, Indiana, United States
  • Metzger, Corinne E., Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Chen, Neal X., Indiana University School of Medicine, Indianapolis, Indiana, United States
  • O'Neill, Kalisha, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Tak, Landon, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Allen, Matthew R., Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Moe, Sharon M., Indiana University School of Medicine, Indianapolis, Indiana, United States
Background

Chronic kidney disease (CKD) progression is associated with deterioration of musculoskeletal health. We hypothesized that voluntary wheel running as compared to forced treadmill would preferentially impact musculoskeletal health in CKD.

Methods

We used a progressive, naturally occurring, CKD rat model (Cy/+ rat)(n=10-12/gr): 1) normal littermates (NL), 2) Cy/+ (CKD) rats, 3) CKD-treadmill (CKD-TM) 4) CKD-wheel (CKD-W). For 10 weeks treadmill rats ran 40 minutes/day, 4 days/week, for 0° grade, wheel rats had 24/7 free access; training volumes similar between the modes. Termination, and blood and tissue collection occurred at 33 weeks. Outcome measures were maximal muscle torque and fatigue, maximal running endurance, and tibia cortical bone morphology. Data analysis included one-way ANOVA with Tukey’s multiple comparisons test.

Results

Overall CKD versus NL impaired cortical bone with increased porosity (mean 0.18±0.12 NL, 2.03±1.8 CKD; p<0.05), and reduced area (mean 6.64±0.43 NL, 5.77±0.58 CKD; p<0.01) and thickness (mean 0.48±0.30 NL, 0.34±0.11 CKD; p<0.001). Skeletal muscle function worsened in CKD (vs NL) with reduced maximal torque (mean 57.3±7.7 NL, 47.6±9.3 CKD; p<0.05) and increased fatigue (mean 42.8±9.9 NL, 56.5±8.7 CKD; p<0.01). Running endurance was significantly reduced in CKD (mean 24.2±3.3 NL, 20.8±4.5 CKD; p<0.05). Treadmill running increased maximal torque (mean 47.6±9.3 CKD, 57.1±8.8 CKD-TM; p<0.05) and running endurance (mean 20.8±4.5 CKD, 25.9±3.9 CKD-TM; p<0.05) when compared to CKD. Wheel running significantly improved maximal running endurance (mean 20.8±4.5 CKD, 24.7.03±2.9 CKD-W; p<0.05), but did not impact maximal muscle torque, muscle fatigue or cortical bone parameters.

Conclusion

CKD deteriorates the musculoskeletal system through cortical bone loss, and reduced muscle strength and greater muscle fatigue. To determine optimal delivery of exercise we compared treadmill to wheel running. Both methods improved maximal running endurance after 10 weeks; however, only treadmill running improved maximal muscle strength. These marginal improvements mimic what is seen in clinical meta-analyses and emphasizes the need for novel approaches to exercise prescription and/or the need for pharmaceutical or nutraceutical treatments to improve musculoskeletal health in advanced CKD.

Funding

  • NIDDK Support