Abstract: SA-PO1097
Changes in the Thyroid, Pituitary, and Gonadal Hormones in CKD Patients During One-Year Follow-Up
Session Information
- CKD Epidemiology, Risk Factors, Prevention - III
November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Rymarz, Aleksandra, Wojskowy Instytut Medyczny - Panstwowy Instytut Badawczy, Warszawa, Mazowieckie, Poland
- Lesniak, Ksymena, Wojskowy Instytut Medyczny - Panstwowy Instytut Badawczy, Warszawa, Mazowieckie, Poland
- Niemczyk, Stanislaw, Wojskowy Instytut Medyczny - Panstwowy Instytut Badawczy, Warszawa, Mazowieckie, Poland
Background
Hormonal disorders are common complications of chronic kidney disease (CKD). Endocrine disturbances interplay with nutritional status and both are associated with kidney function and influence long term outcomes. The aim of the study was to examine changes of serum levels of chosen hormones, changes in kidney function and nutritional parameters in CKD patients during one-year follow-up.
Methods
Male CKD patients with eGFR lower than 45 ml/min/1.73m2 on conservative treatment formed cCKD group and male patients treated with hemodialysis for more than three months formed HD group. In both groups serum levels of total (TT), free testosterone (FT), dehydroepiandrosterone sulfate (DHEA-S), sex hormone binding globulin (SHBG), luteinizing hormone (LH), prolactin (PL), thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), creatinine (Cr), albumin (A) were measured at the moment of inclusion and after one year.
Results
21 men aged 67±7 were included to cCKD group and 20 aged 63±8 to HD group. Over one-year follow-up in cCKD group serum levels of LH, PL and TSH increased significantly whereas DHEA-S decreased. Serum levels of TT, FT, SHBG, fT3, fT4 as well as Cr, A and levels did not change significantly. In HD group over one year follow-up serum levels of fT3 and fT4 significantly decreased. Whereas the rest of parameters did not change significantly.
Conclusion
In male with CKD on conservative treatment significant changes of DHEA, LH, prolactin and TSH were observed during one-year follow-up whereas at the same time Cr, eGFR and nutritional markers did not change significantly. In HD group only fT3 and fT4 decreased significantly. We can suspect that hormonal changes can precede decline in kidney function and deterioration of nutritional status in CKD patients.
| cCKD inclusion | cCKD after one year | p | HD inclusion | HD after one year | p | |
| TT (ng/ml) | 3.9±1.6 | 3.9±1.5 | 0.835 | 2.8±0.9 | 3.0±1.1 | 0.332 |
| FT (pg/ml) | 9.6±4.5 | 10.4±4.5 | 0.205 | 11.6±6.5 | 10.7±4.8 | 0.737 |
| DHEA-S (ug/dl) | 145±89 | 130.2±87.1 | 0.014 | 120±93 | 107.3±85.2 | 0.277 |
| SHBG (ug/ml) | 4.7±1.4 | 4.9±1.4 | 0.532 | 4.6±3.8 | 4.5±2.7 | 0.455 |
| LH (IU/l) | 10.7±8.0 | 13.2±9.3 | 0.019 | 17.8±20 | 17.6±19.2 | 0.411 |
| PRL (ng/ml) | 10.2±3.9 | 13.2±5.6 | <0.001 | 32.5±32.5 | 35.2±28.4 | 0.681 |
| TSH (uIU/ml) | 1.9±1.5 | 2.7±2.8 | 0.042 | 1.7±1.0 | 1.7±1.1 | 0.970 |
| fT3 (pmol/l) | 4.7±0.6 | 4.7±0.8 | 0.808 | 4.0±0.6 | 3.5±0.7 | <0.001 |
| fT4 (pmol/l) | 16.3±3.5 | 17.1±3.7 | 0.085 | 14.6±2.2 | 13.6±2.5 | 0.009 |
| eGFR | 32.9±10.7 | 35.7±19.3 | 0.498 |