Abstract: FR-PO856
Maternal Outcomes Following Nephrology Review in Pregnancy
Session Information
- Women's Health and Kidney Diseases
November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Women's Health and Kidney Diseases
- 2200 Women's Health and Kidney Diseases
Authors
- Stoneman, Sinead, Cork University Hospital, Cork, Cork, Ireland
- Miremberg, Hadas, Cork University Maternity Hospital, Cork, Cork, Ireland
- O'Connell, Blathnaid, Cork University Hospital, Cork, Cork, Ireland
- Cowhig, Cliona, Cork University Hospital, Cork, Cork, Ireland
- Daly, Fionn Patrick, Cork University Hospital, Cork, Cork, Ireland
- Clarkson, Michael, Cork University Hospital, Cork, Cork, Ireland
- Russell, Nóirín, Cork University Maternity Hospital, Cork, Cork, Ireland
- Kenny, Louise, University of Liverpool, Liverpool, United Kingdom
- Plant, Liam, Cork University Hospital, Cork, Cork, Ireland
- Moran, Sarah Margaret, Cork University Hospital, Cork, Cork, Ireland
Background
Chronic kidney disease [CKD] is estimated to affect 3% of pregnant women. Dialysis-requiring pregnancy-associated acute kidney injury [PRAKI] is increasing in incidence, however accurate definitions for non-dialysis requiring PRAKI are lacking.
Methods
We conducted a retrospective cohort study of women who were reviewed by our Obstetric Nephrology Service from January 1st 2007 to March 31st 2023. Maternal and fetal outcomes were collected. Ethical approval was provided by the institution’s ethics committee. Statistical analysis was performed with GraphPad version 7 and R.
Results
459 women met inclusion criteria. We report the interim analysis of 154 pregnancies in 128 women. Mean maternal age at conception was 32.9 ± 5.3 years. 30% of mothers were nulliparous and 25% had hypertension pre-pregnancy. Indication for review was pre-existing CKD (57%), acute kidney injury and/or new proteinuria/hematuria (20%) and newly diagnosed CKD in the index pregnancy (9%). CKD was attributed to urological causes in 44%, glomerulonephritis in 29% and polycystic kidney disease in 15% of the cohort. In women with newly detected CKD in pregnancy, 26% underwent subsequent kidney biopsy. In women with CKD, serum creatinine [sCr] preconception was 73 µmol/L (63-138) and in trimester 2 during pregnancy was 56umol/L. Follow-up sCr at 1 yr was 73 µmol/L (65-94), 3 yrs was 76 µmol/L (65-94), 10 yrs was 87 µmol/L(66-250) and at 15 years was 150 µmol/L (88-850umol/). 3% of all women developed ESKD during follow up.
Conclusion
Results from this single-center study provide longitudinal kidney and maternal outcomes from a large cohort of women who received obstetric nephrology care.
Serial serum creatinine measurements (µmol/L) from pre-conception to 15 years of follow up.