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Abstract: FR-PO838

Effects of Two-Month Low-Sodium (Na+) Diet on Muscle Na+, Fat, and Function in Hemodialysis (HD) Patients

Session Information

Category: Health Maintenance, Nutrition, and Metabolism

  • 1500 Health Maintenance, Nutrition, and Metabolism

Authors

  • Fang, Hsin-Yu, University of Illinois Urbana-Champaign, Urbana, Illinois, United States
  • Jung, Kwan-Jin, University of Illinois Urbana-Champaign, Urbana, Illinois, United States
  • Ramos-Acevedo, Samuel, University of Illinois Urbana-Champaign, Urbana, Illinois, United States
  • Pawelczyk, Kaitlyn, University of Illinois Urbana-Champaign, Urbana, Illinois, United States
  • Wilund, Kenneth Robert, University of Illinois Urbana-Champaign, Urbana, Illinois, United States
Background

Higher muscle sodium concentration ([Na+]) in HD patients is linked with muscle metabolic disturbances. We aimed to test if a 2-month low-Na+ diet would reduce muscle [Na+], thereby improving muscle structure or function in HD patients.

Methods

Eleven HD patients (56±11 y) received 2 and 1 low-Na+ meal(s)/day during the first and second months of intervention, respectively, along with dietary counseling. The [Na+] and fat fraction (FF) in muscles were measured by 3T 23Na- and 1H-MRI at pre- and post-intervention in 6 muscles: tibialis anterior (TA), extensor digitorum longus (EDL), peronei (PER), soleus (SOL), and lateral (LG) and medial (MG) gastrocnemius. Lower-limb muscle function was assessed using the 30s sit-to-stand (STS) test after MRI. Data were analyzed using the paired t test and Pearson’s or Spearman's correlation.

Results

At baseline, muscle [Na+] was inversely correlated with STS score in all muscles except SOL (Fig.1) and tended to positively correlate with FF in MG (r=0.60, P=0.05). There were no significant changes in muscle [Na+] or FF post-intervention in each muscle studied (all P>0.05), with no improvement seen in STS score (P=0.34). An increase in muscle [Na+] from pre- to post-intervention was associated with a decrease in STS score in all muscles except SOL (Fig. 2). There was no correlation between pre- to post-intervention changes in muscle FF and changes in STS score for each muscle (all P>0.05).

Conclusion

Two-months of a low-Na+ diet did not reduce muscle [Na+] in HD patients. However, the inverse correlations between baseline muscle [Na+] and STS score and the changes in muscle [Na+] and STS score, may serve as a rationale for developing new interventions to mitigate muscle dysfunction in HD patients by controlling muscle [Na+].

Funding

  • Private Foundation Support