Abstract: SA-PO121
Exploring Lipid Biomarkers of Cardiac Surgery-Associated AKI Based on Lipidomics
Session Information
- AKI: Biomarkers, Imaging, Interventions
November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 102 AKI: Clinical, Outcomes, and Trials
Authors
- Xu, Youjun, Ningbo No. 2 Hospital, Ningbo, China
- Zhou, Fangfang, Ningbo No. 2 Hospital, Ningbo, China
- Wang, Lailiang, Ningbo No. 2 Hospital, Ningbo, China
- Zhang, Shuzhen, Ningbo No. 2 Hospital, Ningbo, China
- Zheng, Xingyue, Ningbo No. 2 Hospital, Ningbo, China
- Luo, Qun, Ningbo No. 2 Hospital, Ningbo, China
Background
Cardiac surgery-associated acute kidney injury (CSA-AKI) is a frequently occurring complication. Lipids played important roles in many biological pathways and could work as biomarkers of disease. The purpose of this study was to explore lipid biomarkers of CSA-AKI.
Methods
Plasma samples were collected when patients admitted to the ICU after cardiac surgery from 24 CSA-AKI patients and 31 controls. Lipidomic approach based on liquid chromatography mass spectrometer (LC-MS) was used to analyze plasma lipidomic alterations and potential biomarkers for CSA-AKI patients. Univariate and multivariate statistical analyses were utilized to screen the differential lipids between two groups.
Results
Lipidomics analysis detected 4053 lipid species totally. Differentially expressed lipids were screened based on the criteria variable importance at projection (VIP) value > 1, p value < 0.05, and fold change (FC) > 1.5 or < 0.67. Lipidomics identified that 65 lipids satisfied the criteria. The volcano plot showed the results of differential expression of lipids (figure 1). Heat map presented the relative levels of lipids (figure 2).
Conclusion
Lipidomics profiles could change significantly in CSA-AKI patients, and some lipid species were notably upregulated in the early stage of CSA-AKI, which could serve as potential biomarkers for CSA-AKI.
Figure 1. volcano spot
Figure 2. heat map