Abstract: TH-PO234
Depressive Symptoms and Achieving Blood Pressure (BP) Goals in the Systolic Blood Pressure Intervention Trial (SPRINT)
Session Information
- Hypertension and CVD: Clinical - I
November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Hypertension and CVD
- 1602 Hypertension and CVD: Clinical
Authors
- Takyi, Augustine, University of Utah Health, Salt Lake City, Utah, United States
- Bissada, George, University of Utah Health, Salt Lake City, Utah, United States
- Hartsell, Sydney Elizabeth, University of Utah Health, Salt Lake City, Utah, United States
- Boucher, Robert E., University of Utah Health, Salt Lake City, Utah, United States
- Wei, Guo, University of Utah Health, Salt Lake City, Utah, United States
- Singh, Ravinder, University of Utah Health, Salt Lake City, Utah, United States
- Sarwal, Amara, University of Utah Health, Salt Lake City, Utah, United States
- Beddhu, Srinivasan, University of Utah Health, Salt Lake City, Utah, United States
Background
We examined the hypothesis that depressive symptoms might result in lower adherence to systolic BP intervention (SBP goal < 120 vs. < 140 mmHg) in a post-hoc analysis of SPRINT data.
Methods
Based on baseline depressive symptoms assessed by the Patient Health Questionnaire (PHQ) - 9 scores, we defined depressive symptom groups as no (score = 0), minimal/mild (score =1-9), moderate/severe (score = 10-27) depressive symptoms. We used mixed effects models to relate baseline PHQ9 groups to post-randomization delta SBP (achieved standard arm SBP -achieved intensive arm SBP and delta number of antihypertensives).
Results
In the 9340 included SPRINT participants, achieved SBP by baseline PHQ9 groups in standard and intensive arms are presented in Fig 1. Delta SBP and delta antihypertensives are presented in Table 1.
Conclusion
Moderate/severe depressive symptoms were associated with less separation of achieved SBP in SPRINT. Addressing depressive symptoms might be important to achieve adherence to interventions.
Table 1
| Depressive symptoms | Delta SBP | Delta # antihypertensives |
| Absent | 14.8 (14.4, 15.3) | -0.8 (-0.8,-0.7) |
| Mild | 14.0(13.4,14.6) | -0.7 (-0.7,-0.6) |
| Moderate/Severe | 9.0(5.6,12.4) | -0.8(-1.0,-0.5) |
Funding
- NIDDK Support