Abstract: SA-PO688
The Association Between Urine Oxalate and Citrate May Not Be Diet Driven
Session Information
- Fluid, Electrolyte, Acid-Base Disorders: Clinical - II
November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Fluid, Electrolytes, and Acid-Base Disorders
- 1102 Fluid, Electrolyte, and Acid-Base Disorders: Clinical
Authors
- Prochaska, Megan, University of Chicago Division of the Biological Sciences, Chicago, Illinois, United States
- Coe, Fredric L., University of Chicago Division of the Biological Sciences, Chicago, Illinois, United States
- Worcester, Elaine M., University of Chicago Division of the Biological Sciences, Chicago, Illinois, United States
Background
Higher urine oxalate excretion has been associated with higher urine citrate excretion and the magnitude of the association is larger in non-kidney stone patients compared with kidney stone patients. The mechanism for this association may be due to simultaneous dietary intake oxalate and citrate in fruits and vegetables or transporter linkage of SLC26A6 and NaDC1 in the kidney .
Methods
Eleven participants, including 3 kidney stone patients, were admitted to the clinical research center and given sodium oxalate. Timed pre-sodium oxalate (1) and post-sodium oxalate (6) urine samples were collected every hour. Urine composition was measured and excretion rates of oxalate and citrate calculated at each period. Mean and standard error were graphed per period and mixed methods longitudinal models were generated to compare change over time versus pre-oxalate value (Period 1) of oxalate and citrate excretion.
Results
Eight of the 11 participants were women with mean age 54 years. Urine oxalate and citrate excretions were higher than pre-oxalate (Period 1) at Periods 4 to 6, and Periods 4 and 5, respectively (Figure 1).
Conclusion
After consumption of sodium oxalate participants had an increase in urine oxalate excretion, as expected, but they also had an increase in urine citrate excretion. The association between oxalate and citrate excretion may not be completely driven by dietary intake.
Figure 1. Excretion of oxalate and citrate per study period. Period 1 represents pre-sodium oxalate baseline value. Periods 2-7 are post-sodium oxalate and timed every 1 hour. Starred periods denote where an indiviudal period was statistically higher than Period 1 in the mixed methods longitudinal model.
Funding
- NIDDK Support