Abstract: SA-PO1120
The Relationship Between Smoking Cessation and Atherosclerotic Cardiovascular Disease Development Among Patients with CKD
Session Information
- CKD Epidemiology, Risk Factors, Prevention - III
November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Joo, Young Su, Yonsei University Institute of Kidney Disease, Seodaemun-gu, Seoul, Korea (the Republic of)
- Koh, Hee Byung, Yonsei University Institute of Kidney Disease, Seodaemun-gu, Seoul, Korea (the Republic of)
- Park, Jung Tak, Yonsei University Institute of Kidney Disease, Seodaemun-gu, Seoul, Korea (the Republic of)
- Yoo, Tae-Hyun, Yonsei University Institute of Kidney Disease, Seodaemun-gu, Seoul, Korea (the Republic of)
- Oh, Kook-Hwan, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
- Kang, Shin-Wook, Yonsei University Institute of Kidney Disease, Seodaemun-gu, Seoul, Korea (the Republic of)
- Han, Seung Hyeok, Yonsei University Institute of Kidney Disease, Seodaemun-gu, Seoul, Korea (the Republic of)
Background
Previous studies evidenced that smoking is associated with higher atherosclerotic cardiovascular disease (ASCVD) and mortality risk. However, whether quitting smoking is associated with reduced ASCVD risk compared to maintaining smoking in patients with chronic kidney disease (CKD) is unclear. Here we evaluated the association between smoking cessation and ASCVD in patients with CKD.
Methods
We analyzed 1698 participants with non-dialysis dependent CKD from the KoreaN cohort study for Outcome in patients With Chronic Kidney Disease (KNOW-CKD). Key exclusion criteria were 1) kidney failure requiring renal replacement therapy, 2) history of ASCVD at enrollment, and 3) missing data for smoking history. We categorized participants according to smoking history and compared the risk of ASCVD and all-cause mortality. The ASCVD event was defined as a composite of myocardial infarction, stroke, or cardiovascular mortality.
Results
During 12,168 person-years of follow-up (median 8.0 years), the ASCVD event occurred in 52 (3.06%) participants, and 111 (6.26%) participants died among the KNOW-CKD participants. There were 19 (2.03%), 18 (4.09%), and 15 (4.64%) ASCVD events in never (n=935), former (n=440), and current smokers (n=323), respectively. The incidence of ASCVD was higher in current smokers (6.6 per 1000 person-years) than in former (5.7 per 1000 person-years) and never-smokers (2.8 per 1000 person-years) (P=0.02). A multivariable Cox regression showed that continuing smoking is significantly associated with ASCVD even after adjustment of age, sex, diabetes mellitus, estimated glomerular filtration ratio, and proteinuria. However, the risk of ASCVD events in former smokers was comparable to never smokers (Hazard ratio, 1.83; 95% confidence interval, 0.95-3.52).
Conclusion
In the present analysis, quitting smoking was associated with reduced risk for ASCVD compared to continuing smoking in CKD patients.
Funding
- Government Support – Non-U.S.