Abstract: FR-PO825
Poor Vitamin K Status and Inflammation in Patients with CKD
Session Information
- Health Maintenance, Nutrition, Metabolism - II
November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Mafra, Denise, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil
- Lima, Ligia Soares, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
- Ribeiro, Marcia Maria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
- Cardozo, Ludmila Fmf, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil
- Maassen, Cecile, Universiteit Maastricht, Maastricht, Limburg, Netherlands
- Ribeiro-Alves, Marcelo, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
- Lux, Petra, Universiteit Maastricht, Maastricht, Limburg, Netherlands
- Schurgers, Leon J., Universiteit Maastricht, Maastricht, Limburg, Netherlands
Group or Team Name
- Renal Nutrition - UFF.
Background
Vitamin K is vital to cardiovascular and bone health and can mitigate inflammation. Vitamin K inhibits the activation of NF-κB, which seems related to vitamin K-dependent proteins, inhibiting the production of IL-6 by macrophages. Patients with CKD frequently present a deficiency of vitamin K. Considering the high mortality rate linked to cardiovascular disease (CVD), reduced quality of life and poor outcomes related to inflammation, it is essential to understand the relationship between vitamin K deficiency and inflammation, raising the possibility of new therapeutic targets in treating CKD-induced CVD. This study aimed to evaluate the correlation between vitamin K status and inflammation in patients with CKD (non-dialysis and hemodialysis - HD).
Methods
108 patients undergoing HD (51 male, 52 yrs) and 23 non-dialysis patients (7 male, 58 yrs) were evaluated. Plasma desphospho-uncarboxylated matrix Gla-protein (dp-ucMGP), a functional vitamin K deficiency biomarker, was analysed using the IVD CE-marked chemiluminescent InaKtif MGP assay on the IDS-iSYS system. IL-6 plasma levels were evaluated by ELISA. The results were adjusted for age, sex and BMI.
Results
HD patients had significantly higher values of dp-ucMGP [728 (IQR=724) pmol/L] than non-dialysis patients [563 (IQR=296) pmol/L] (p=0.05), indicating vitamin K deficiency. Furthermore, a significant positive correlation was observed between dp-ucMGP and IL-6 levels in HD patients, which reflects elevated levels of IL-6 in patients with vitamin K deficiency (Fig. 1).
Conclusion
The results reveal a positive correlation between vitamin K deficiency and the pro-inflammatory biomarker IL-6 in patients with CKD. Vitamin K supplementation may be a strategy to mitigate inflammation in these patients.
Fig 1. Correlation between dp-ucMGP and IL-6 plasma levels of HD patients. Pearson correlations were performed with residuals of linear fixed effects models, including confounders (Age, Sex, BMI, and time on dialysis).
Funding
- Government Support – Non-U.S.