Abstract: FR-PO955
Association Between Weight Change from 20 Years of Age and the Risk of All-Cause and Cardiovascular Mortality in Patients with CKD
Session Information
- CKD Epidemiology, Risk Factors, Prevention - II
November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Okamura, Kazuhiro, Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Fukuoka, Japan
- Tanaka, Shigeru, Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Fukuoka, Japan
- Kitamura, Hiromasa, Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Fukuoka, Japan
- Hiyamuta, Hiroto, Fukuoka Daigaku Igakubu Daigakuin Igaku Kenkyuka, Fukuoka, Fukuoka, Japan
- Tsuruya, Kazuhiko, Nara Kenritsu Ika Daigaku Igakubu Igakuka Daigakuin Igaku Kenkyuka, Kashihara, Nara, Japan
- Kitazono, Takanari, Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Fukuoka, Japan
- Nakano, Toshiaki, Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Fukuoka, Japan
Background
Weight changes from a young age have been reported as being linked to poor life outcomes in the general population. However, little is known concerning the association between weight changes from a young age and life expectancy in patients with chronic kidney disease (CKD).
Methods
The data of 2,806 non-dialysis CKD patients who participated in the Fukuoka Kidney disease Registry (FKR) Study, a multi-center observational study, were analyzed. All-cause mortality was the primary outcome, while cardiovascular mortality was a secondary outcome. The covariate of interest was weight change, defined as the difference between body weight at study enrolment and that at 20 years of age. We estimated the risks of mortality for participants with weight changes of ≥5 or <5 kg using Cox proportional hazards models, as compared to those with stable weights.
Results
In total, 243 participants (8.7% of the total) died from all-cause, and 62 participants died from cardiovascular disease within the 5-year observation period. The risk of all-cause mortality was significantly higher in the weight loss group than in the stable weight group (multivariable-adjusted hazard ratio [95% confidence interval], 2.11 [1.52–2.93]). In addition, the risk of cardiovascular mortality was significantly higher in the weight loss group than in the stable weight group (multivariable-adjusted hazard ratio [95% confidence interval], 2.48 [1.32–4.64]). No significant associations were found between weight gain and the risks of all-cause and cardiovascular mortality.
Conclusion
Weight loss since 20 years of age is associated with increased risks of all-cause and cardiovascular mortality in non-dialysis CKD patients.