Abstract: FR-PO809
Measurement Properties of the Most Common Performance-Based Measures of Physical Function in CKD: A Systematic Review
Session Information
- Health Maintenance, Nutrition, Metabolism - II
November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- MacRae, Jennifer M., University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada
- Harasemiw, Oksana, University of Manitoba Max Rady College of Medicine, Winnipeg, Manitoba, Canada
- Lightfoot, Courtney Jane, University of Leicester, Leicester, United Kingdom
- Thompson, Stephanie E., University of Alberta Faculty of Medicine & Dentistry, Edmonton, Alberta, Canada
- Bohm, Clara, University of Manitoba Max Rady College of Medicine, Winnipeg, Manitoba, Canada
- Wytsma-Fisher, Kathryn A., University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada
- Koufaki, Pelagia, Queen Margaret University, Musselburgh, United Kingdom
- Wilkinson, Thomas James, University of Leicester, Leicester, United Kingdom
Background
There is wide heterogeneity in physical function tests for clinical and research use in chronic kidney disease (CKD). The aim of this review was to identify and evaluate the most frequent physical function measures in terms of clinimetric properties.
Methods
MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, CINAHL, Scopus, and Web of Science were searched from inception to March 2022, identifying studies which evaluated a clinimetric property (validity, reliability, measurement error, responsiveness) of an objectively measured performance-based physical function outcome. All ages and any stage of CKD were included. The most common tests (defined as having 4 or more studies) are described in terms of reliability and validity.
Results
50 studies with 21,315 participants were included, the majority were HD. Clinimetric properties were reported for 22 physical function tests; the following were most common: Hand grip strength (HGS), six minute walk test (6MWT), V02 peak, short physical performance battery (SPPB), gait speed, Sit to stand test-60 (STS-60), timed up and go (TUG), STS-5 and incremental shuttle walk test (ISWT). Very few studies reported properties of criterion (ISWT) and responsiveness (V02 peak and 6MWT).
Conclusion
The SPPB demonstrates high GRADE evidence for construct validity, reliability and measurement error. The next best tests include: 6MWT and TUG with high GRADE for reliability and measurement error. This review is an important step towards standardizing a core outcome set of tools to measure physical function in research and clinical settings for CKD.
Physical function tests GRADE evidence
| Physical function test (number of studies) | Construct Validity | Reliability | Measurement Error |
| HGS (13) | Low | Low | Moderate |
| 6MWT (11) | Low | High | High |
| SPPB (10) | High | High | High |
| Gait speed (8) | Moderate | Moderate | Very Low |
| STS-5 (8) | High | Moderate | Low |
| V02 peak (8) | Low | Low | Low |
| TUG (7) | Moderate | High | High |
| STS-60 (6) | Moderate | High | Moderate |
| STS-30(4) | Low | High | Moderate |
| ISWT (4) | Moderate | Low | Low |