Kidney Week

Abstract: SA-PO1117

Monocyte to High-Density Lipoprotein Cholesterol Ratio (MHR) and Carotid Intima-Media Thickness (cIMT) in Patients with CKD: Secondary Analysis of Pooled Clinical Study Data

Session Information

• CKD Epidemiology, Risk Factors, Prevention - III
  November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Oh, Ester, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States

Ester Oh,

• You, Zhiying, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States

Zhiying You,

• Jovanovich, Anna, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States

Anna Jovanovich,

• Nowak, Kristen L., University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States

Kristen L. Nowak,

Background

Monocyte to high-density lipoprotein cholesterol ratio (MHR) is an emerging prognostic marker of cardiovascular diseases, including atherosclerosis. Circulating monocytes contribute to plaque development, whereas, high-density lipoprotein (HDL) cholesterol neutralizes the pro-inflammatory and pro-oxidative properties of monocytes, resulting in an atheroprotective effect. Indeed, in the general population, MHR is associated with carotid intima-media thickness (cIMT; a measure of subclinical atherosclerosis). However, this association has not been assessed in a cohort with chronic kidney disease (CKD), a population with atherosclerotic risk. The current study aimed to examine whether MHR is associated with cIMT in patients with stage 3-4 CKD.

Methods

This pooled analysis included baseline data from four clinical studies (2 published [PMID: 27647856; 36636757] and 2 unpublished [NCT Number: NCT04911491; NCT05471518]) that measured monocyte number, serum HDL cholesterol levels, and cIMT in patients with stage 3-4 CKD. Univariate and multivariate regression models were used to evaluate associations of MHR with cIMT and to further adjust for clinically relevant covariates.

Results

A total of 59 participants (39% female; 76% white; mean±SD age 65±10 years; eGFR 41±13 mL/min/1.73m²; MHR 14±7; cIMT 0.73±0.26 mm) were included. There was an association between MHR and cIMT (β=0.286; P=0.03) in the unadjusted model (Figure). The association between MHR and cIMT was slightly attenuated after fully adjusting for age, sex, body mass index, and low-density lipoprotein cholesterol (β=0.266; P=0.06).

Conclusion

MHR may be associated with cIMT in patients with CKD; this observation should be explored further in a larger cohort.

Scatter plot of the association between monocyte to high-density lipoprotein cholesterol ratio (MHR) and carotid intima-media thickness (cIMT)

Funding

• NIDDK Support