Kidney Week

Abstract: FR-PO847

Albuminuria and Vascular Health in Females with CKD

Session Information

• Women's Health and Kidney Diseases
  November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Women's Health and Kidney Diseases

• 2200 Women's Health and Kidney Diseases

Authors

• Pattar, Badal S.B., University of Calgary, Calgary, Alberta, Canada

Badal S.B. Pattar,

• Larsen, Nicole, University of Calgary, Calgary, Alberta, Canada

Nicole Larsen,

• Ahmed, Sofia B., University of Calgary, Calgary, Alberta, Canada

Sofia B. Ahmed,

• Holodinsky, Jessalyn K., University of Calgary, Calgary, Alberta, Canada

Jessalyn K. Holodinsky,

• Kharbanda, Sakshi, University of Calgary, Calgary, Alberta, Canada

Sakshi Kharbanda,

• Rabi, Sarah M., University of Calgary, Calgary, Alberta, Canada

Sarah M. Rabi,

• Sola, Darlene Y., University of Calgary, Calgary, Alberta, Canada

Darlene Y. Sola,

• Dumanski, Sandi M., University of Calgary, Calgary, Alberta, Canada

Sandi M. Dumanski,

Background

Cardiovascular (CV) disease is the leading cause of death in chronic kidney disease (CKD), and elevated CV risk occurs earlier in the CKD disease course in females compared to males. Albuminuria, a marker of CKD severity, has been independently associated with CV disease in females, however the mechanism of this association is not yet understood. This study aimed to determine the association between albuminuria and markers of vascular health, including mean arterial pressure (MAP) and arterial stiffness, as measured by aortic augmentation index (AIx) and pulse-wave velocity (PWV), in females with CKD.

Methods

An exploratory cross-sectional study recruited 54 females with CKD from nephrology clinics in Calgary, Alberta. Albuminuria was quantified by collection of a midstream urine and measurement of urine albumin-to-creatine ratio (ACR). Using standardized protocols, blood pressure and arterial stiffness were measured. Multiple linear regression analysis was used to estimate the association between urine ACR and each marker of vascular health.

Results

Albuminuria was significantly associated with MAP (R² = 0.20; p = 0.001) and AIx (R² = 0.21; p = 0.006), but was not associated with PWV (R² = 0.11; p = 0.127).

Conclusion

Disruptions in vascular health, specifically related to elevated blood pressure and increased peripheral wave reflection, may represent the pathophysiologic mechanism by which albuminuria is associated with increased CV risk in females with CKD. These risk factors may represent modifiable risk factors that serve as treatment targets for CV risk reduction in this important population.

Funding

• Government Support – Non-U.S.