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Abstract: TH-PO581

Effects of Obesity on Pheresis Outcomes

Session Information

  • Pathology and Lab Medicine
    November 03, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
    Abstract Time: 10:00 AM - 12:00 PM

Category: Pathology and Lab Medicine

  • 1700 Pathology and Lab Medicine

Authors

  • Bobba, Aniesh, John H Stroger Jr Hospital of Cook County, Chicago, Illinois, United States
  • Gangu, Karthik, University of Missouri, Columbia, Missouri, United States
  • Krishnaraju, Ellil O., John H Stroger Jr Hospital of Cook County, Chicago, Illinois, United States
  • Mariyam joy, Christina, Medical College of Wisconsin, Milwaukee, Wisconsin, United States
Background

The prevalence of obesity is on the uptrend in the United States. The degree of obesity can affect the estimation of plasma volume calculations while performing pheresis. In this study, we investigate the effect of Body Mass Index(BMI) on post-pheresis hospital outcomes.

Methods

We performed a retrospective study by utilizing the 2016 to 2018 National inpatient sample, and we included patients aged 18 or older who underwent pheresis for any cause during hospitalization. Patients were subdivided based on BMI. Categorical variables were compared using the Chi-square test. A multivariate logistic regression model was used for all-cause mortality and intubation rates.

Results

Of the 77,170 patients who had pheresis 50,222 patients were obese (BMI>30),a total of 23,922 were in the extreme obesity(BMI>40) category. The mean age in extreme obesity group was 49 years and women formed 66.15% of the group . Extreme Obesity was associated with increased odds of intubation and in-hospital mortality. The in-hospital mortality rate adjusted Odds ratio(aOR) was 1.32(1.02-1.72,p = 0.03) and need for mechanical ventilation 1.68 (1.42-2.01,p <0.001) .Patients with BMI< 25 had increased odds of mechanical ventilation(aOR = 1.54,p<0.001) and trend towards increased mortality(aOR =1.28,p=0.059).

Conclusion

Pheresis in extreme obesity is associated with an increased risk of mechanical ventilation and in-hospital mortality. Further investigations into interventions and protocols to improve outcomes should be undertaken.