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Abstract: FR-PO295

Time-Restricted Feeding Outperforms Periodic Fasting Head-to-Head in Slowing and Reversing Progression of Polycystic Kidney Disease in the Han:SPRD Rat Model

Session Information

Category: Genetic Diseases of the Kidneys

  • 1101 Genetic Diseases of the Kidneys: Cystic

Authors

  • Torres, Jacob A., University of California Santa Barbara, Santa Barbara, California, United States
  • Holznecht, Nickolas J., University of California Santa Barbara, Santa Barbara, California, United States
  • Asplund, David Allan, University of California Santa Barbara, Santa Barbara, California, United States
  • Kroes, Bradley Christian, University of California Santa Barbara, Santa Barbara, California, United States
  • Strubl, Sebastian, University of California Santa Barbara, Santa Barbara, California, United States
  • Schimmel, Margaret, University of California Santa Barbara, Santa Barbara, California, United States
  • Weimbs, Thomas, University of California Santa Barbara, Santa Barbara, California, United States
Background

We previously reported that interventions that induce the state of ketosis, including caloric restriction, time-restricted feeding, ketogenic diet and extended fasting, ameliorate or reverse polycystic kidney disease progression in animal models. We had found that time-restricted feeding was highly effective in juvenile Han:SPRD rats and that a 48-hour extended fast induced apoptosis in cystic epithelia. To expand on those findings, we now compared, head-to-head, periodic 48-hour fasting against a daily 16:8 time-restricted feeding regimen in both juvenile and adult Han:SPRD rats.

Methods

Juvenile and adult Han:SPRD rats were fasted weekly for 48 hours and then given ad libitum access to food for 5 days before being fasted again for 48 hours. This was repeated for 5 weeks from age 3 weeks to 8 weeks in juveniles and for 4 weeks in adults from age 8 weeks to 12 weeks. For daily time-restricted feeding, rats were given ad libitum access to food for 8 hours a day and were fasted for the remaining 16 hours. This was performed in adult rats from weeks 8 weeks to 12 weeks of age.

Results

All treatments led to a decrease in serum creatinine and markers of cystic disease progression. The beneficial effects of daily time-restricted feeding significantly exceeded that of periodic 48-hour fasting, leading to a partial reversal of established renal cystic disease in adult rats.

Conclusion

These results suggest that daily time-restricted feeding is a more potent intervention than periodic fasting. This study has important implications for translation into the clinic for the dietary management of individuals with ADPKD and the design of future clinical studies to assess outcomes of such interventions.

Funding

  • Private Foundation Support