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Abstract: TH-PO805

Urinary Sodium, Potassium, and Kidney Function in West Africans

Session Information

Category: Health Maintenance‚ Nutrition‚ and Metabolism

  • 1400 Health Maintenance‚ Nutrition‚ and Metabolism

Authors

  • Ilori, Titilayo O., Boston University School of Medicine, Boston, Massachusetts, United States
  • Adebile, Temitayo M., Boston University School of Medicine, Boston, Massachusetts, United States
  • Solarin, Adaobi, Lagos State University Teaching Hospital, Lagos, Lagos, Nigeria
  • Mamven, Manmak, University of Abuja, Abuja, Federal Capital Territory, Nigeria
  • Omotoso, Bolanle Aderonke, Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Osun State, Nigeria
  • Raji, Yemi R., University College Hospital Ibadan, Ibadan, Oyo, Nigeria
  • Ulasi, Ifeoma I., University of Nigeria, Nsukka, Enugu, Nigeria
  • Zhao, Runqi, Boston University School of Medicine, Boston, Massachusetts, United States
  • Gbadegesin, Rasheed A., Duke University School of Medicine, Durham, North Carolina, United States
  • Parekh, Rulan S., Women's College Hospital, Toronto, Ontario, Canada
  • Salako, Babatunde Lawal, University of Ibadan, Ibadan, Oyo, Nigeria
  • Adu, Dwomoa, University of Ghana Medical Centre, Accra, Accra, Ghana
  • Anderson, Cheryl A., University of California San Diego, La Jolla, California, United States
  • Ojo, Akinlolu, University of Kansas School of Medicine, Kansas City, Kansas, United States
  • Amira, Christiana Oluwatoyin, Lagos University Teaching Hospital, Surulere, Lagos, Nigeria
  • Waikar, Sushrut S., Boston University School of Medicine, Boston, Massachusetts, United States
Background

Dietary intake of sodium (Na) and potassium (K) may impact kidney function and outcomes, but data are conflicting. Our goal was to examine associations of 24hr urine K and Na (as proxies for dietary intake) with kidney function in Africans with CKD and compare our findings to a U.S.-based CKD cohort, the Chronic Renal Insufficiency (CRIC) study.

Methods

We included participants in the Diet, CKD and ApolipoproteinL1 study (DCA, n=619) ancillary to the Human Hereditary and Health in Africa Kidney Disease study. The exposures were calibrated, log transformed 24hr -UNa, UK and Na/K ratio. Outcomes were calculated eGFR and 24hr-urine protein (Uprotein). We utilized generalized linear regression with a random intercept for clinical center to estimate crude and adjusted beta coefficients and 95% CI. We performed similar analyses in 3,459 participants in CRIC.

Results

Median UNa excretion was lower in DCA than in CRIC [134 (104-175) vs. 160 (118-215) mmol/24hr, p <0.001]. Median UK excretion was lower in DCA than in CRIC [36 (28-48) vs 55 (40-74) mmol/24hr (p <0.001)]. Findings on the associations of Una and UK with eGFR and Uprotein were directionally consistent. Higher UK was associated with higher eGFR in DCA and CRIC participants. Higher 24hr-UNa was associated with higher Uprotein excretion but not eGFR in both cohorts. The UNa/UKratio was associated with lower eGFR and higher Uprotein in both cohorts (see figure).

Conclusion

Cross-sectional associations with eGFR and proteinuria were similar in West Africans and Americans, with evidence for associations of higher UK with higher eGFR, and higher UNa with higher proteinuria.

UNa, UK, EGFR and Proteinuria

Funding

  • NIDDK Support