ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on X

Kidney Week

ASN / Education & Meetings / Kidney Week /

Please note that you are viewing an archived section from 2022 and some content may be unavailable. To unlock all content for 2022, please visit the archives.

Abstract: FR-PO111

Kidney Donors With and Without Post-Donation AKI: Comparison of Baseline Characteristics and Long-Term Outcomes

Session Information

Category: Acute Kidney Injury

  • 101 AKI: Epidemiology‚ Risk Factors‚ and Prevention

Authors

  • Akkari, Abdel-Rauof M., Penn State College of Medicine, Hershey, Pennsylvania, United States
  • Hafid, Mistafa, Penn State College of Medicine, Hershey, Pennsylvania, United States
  • Abdulbasit, Muhammad, Penn State College of Medicine, Hershey, Pennsylvania, United States
  • Salameh, Omar Khaleel Mohammad, Penn State College of Medicine, Hershey, Pennsylvania, United States
  • Ghahramani, Nasrollah, Penn State College of Medicine, Hershey, Pennsylvania, United States
Background

There is an increasing demand for kidney transplantation, especially from living donors. This has necessitated better understanding of medium-term and long-term risks of kidney donation. Using a large multicenter cohort, we analyzed the differences in demographic characteristics in donors who developed acute kidney injury (AKI) within the first year after donation with those who did not develop AKI.

Methods

We performed a retrospective multi-center cohort study using TriNetX Research Network database, a federated medical records network, to identify 42,955 donors ≥ 18 years from 59 healthcare organizations (HCOs) in the United States. From this group, we then identified donors who had a confirmed diagnosis of AKI within a year of donation. We calculated the odds ratio (OR) and 95% confidence interval (CI) of diagnosis of End Stage Renal Disease (ESRD) and death in the first five years after donation.

Results

3,055 donors (from 39 HCOs) had a confirmed diagnosis of AKI within the first year after donation. Patients in the AKI group were older at time of donation (44.2 ± 13.5 years vs. 40.8 ± 12.9 years; p<0.0001), and more likely to:
● be male (p<0.001)
● have a Body Mass Index (BMI) >30 kg/m2 p<0.001)
● have a diagnosis of hypertension at time of donation (p<0.001)
● be on a diuretic agent at time of donation (p<0.001)
● be nicotine dependent (p<0.001)

Within the first five years after donation, a total of 5554 donors (1874 with history of AKI) were diagnosed with ESRD and 1266 donors (501 with AKI) died. After propensity matching, AKI was associated with higher odds of ESRD (OR:15.2; CI:14.1 to 16.5), and mortality (OR: 9.9; CI: 8.8 to 11.2).

Conclusion

Among kidney donors, those who developed AKI within the first year of donation were more likely to be older at time of donation, male, have a BMI > 30 kg/m2, carry a diagnosis of hypertension and be on a diuretic at time of donation, and to be nicotine dependent. AKI within first year of donation was associated with higher likelihood of ESRD and death within five years after donation.