Abstract: TH-PO068
AKI Among Patients With Multi-Drug Resistant Infection: A Study From Jordan
Session Information
- AKI: Biomarkers, Risk Factors, Treatments, Outcomes
November 03, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 102 AKI: Clinical‚ Outcomes‚ and Trials
Authors
- Oweis, Ashraf Omar, Jordan University of Science and Technology Faculty of Medicine, Irbid, Jordan
- Alshelleh, Sameeha A., The University of Jordan, Amman, Amman, Jordan
Background
Acute kidney injury(AKI) is a well-known complication for hospitalized patients especially in the intensive care unit. Sepsis and various infections play major role in increasing the incidence of AKI. In our study we are evaluating the risk for Multidrug resistant (MDR) infections and its effect on incidence of AKI,hospitalization,need for dialysis and mortality.
Methods
In a retrospective study design, data was collected from all adult patients with a positive multi-drug resistant culture who were admitted to King Abdullah University Hospital (KAUH). Records of 436 patients who were admitted to general floors or the intensive care units (ICU)between January 2017 – December 2018 with at least one year follow up and had infection with positive multidrug resistant cultures were reviewed
Results
The mean age for the patients was 57.3 years (SD± 23.1) and 58.5% were males. The most common source of positive culture was sputum culture 50%, followed by wound culture 22.2%. The incidence of AKI was 59.2% and most cases were in stage 3 AKI (41%). The most isolated microorganism was Acinetobacter baumannii 76.8% followed by Pseudomonas aeruginosa 14.9% (picture 2).
On multivariate analysis, age (OR 1.1, 95% CI 1.1–1.2, P=0.001), HTN (OR 1.8, 95% CI 1.0–3.3, P=0.02), DM (OR 1.1, 95% CI 0.6-1.9, P=0.69) and the use of foley catheter on chronic bases (OR 4.3, 95% CI 2.6–6.8, P<0.0001) were a strong predictors of AKI. Among patients with AKI; 74.4% died in comparison to 44.4% (p<0.001).
Conclusion
In patients with MDR incidence for AKI ,hospitalization, and mortality is high. Early detection and addressing of the problem may decrease bad outcomes, health education for decreasing antibiotic abuse is needed to decrease MDR.