Abstract: TH-PO800
Association of Plant-Based Protein Intake With Cognitive Function in Adults With CKD
Session Information
- Health Maintenance, Nutrition, Metabolism
November 03, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance‚ Nutrition‚ and Metabolism
- 1400 Health Maintenance‚ Nutrition‚ and Metabolism
Authors
- Perez, Luis M., University of Colorado Denver School of Medicine, Aurora, Colorado, United States
- You, Zhiying, University of Colorado Denver School of Medicine, Aurora, Colorado, United States
- Kendrick, Jessica B., University of Colorado Denver School of Medicine, Aurora, Colorado, United States
Background
Patients with chronic kidney disease (CKD) have accelerated cognitive aging and cognitive function worsens as kidney function declines. Diets higher in plant-based proteins are associated with better survival in patients with CKD. Whether diets high in plant-based proteins are associated with cognitive function in adults with CKD is unclear.
Methods
Using NHANES 2011-2012 data, we included participants aged 60 years and older with cognitive and dietary data available. We calculated plant-based protein intake from dietary records by linking food database codes with standard references. CKD was defined as urine albumin:creatinine ≥30mg/g and/or eGFR <60 mL/min). Plant protein intake was examined categorically with high vs. low intake defined by median levels. Primary cognitive outcomes included: 1) Consortium to Establish a Registry for Alzheimer’s disease (CERAD); 2) the Animal Fluency test (AFT); and 3) the Digit Symbol Substitution test (DSST). Regression analysis models were used to examine the association between plant-based protein intake and cognition.
Results
We included 322 participants with CKD. The mean age and eGFR were 72±7 years and 60.5±22.4 ml/min/1.73m2, respectively. Over half of the participants were male (52%) and the majority were Non-Hispanic White (47%). Median (IQR) plant protein intake was 19 (13-27)g. Higher plant-based protein intake was significantly associated with higher cognitive scores on CERAD and AFT in the fully adjusted model (Table). Higher plant-based protein intake was not associated with DSST in the fully adjusted model.
Conclusion
Plant-based protein appears to be a significant predictor of cognitive score measures in adults with CKD. It is possible that plant-based protein intake represents lower dietary acid load or other healthy habits that may improve cognitive performance or be associated with increased cognitive function.
Association of Plant-Based Protein Intake with Cognition in CKD
| CERAD Total Score | AFT Score | DSST Score | ||||
| High plant protein vs. low, g | β-estimate (95% CI) | p-value | β-estimate (95% CI) | p-value | β-estimate (95% CI) | p-value |
| Unadjusted | 1.96 (-0.03 to 3.94) | 0.05 | 1.58 (-0.34 to 3.50) | 0.10 | 5.75 (-0.98 to 12.47) | 0.09 |
| Model 1 | 1.94 (0.22 to 3.65) | 0.03 | 1.51 (0.45 to 2.57) | <0.01 | 5.29 (1.94 to 8.63) | <0.01 |
| Model 2 | 1.54 (0.08 to 3.00) | 0.04 | 1.21 (0.33 to 2.08) | 0.01 | 2.01 (-0.63 to 4.65) | 0.12 |
Model 1: age, sex, race/ethnicity and BMI Model 2: Model 1 + dietary animal protein, diabetes, hypertension, education
Funding
- NIDDK Support