Abstract: TH-PO769
Albuminuria in Older Adults: Data on Prevalence and Trends Over 8 Years in the Berlin Initiative Study (BIS)
Session Information
- Voices, Choices, and Outcomes of Older Adults with CKD
November 03, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
Abstract Time: 10:00 AM - 12:00 PM
Category: Geriatric Nephrology
- 1200 Geriatric Nephrology
Authors
- Bothe, Tim, Charite Universitatsmedizin Berlin, Berlin, Berlin, Germany
- Schaeffner, Elke, Charite Universitatsmedizin Berlin, Berlin, Berlin, Germany
- Mielke, Nina, Charite Universitatsmedizin Berlin, Berlin, Berlin, Germany
- Schneider, Alice, Charite Universitatsmedizin Berlin, Berlin, Berlin, Germany
- Barghouth, Muhammad, Charite Universitatsmedizin Berlin, Berlin, Berlin, Germany
- van der Giet, Markus, Charite Universitatsmedizin Berlin, Berlin, Berlin, Germany
- Kuhlmann, Martin K., Vivantes Klinikum im Friedrichshain, Berlin, Berlin, Germany
- Ebert, Natalie, Charite Universitatsmedizin Berlin, Berlin, Berlin, Germany
Background
Data on the course of albumin-creatinine ratio (ACR) in the elderly are scarce. Identifying patterns of ACR progression is important for a better understanding of albuminuria in old age.
Methods
We used data of the BIS, a community-dwelling cohort of 2,069 persons aged 70 or older. Baseline visit was conducted between 2010 and 2011, followed by four biennial follow-up visits. Prevalence of albuminuria (no: ACR<30 mg/g; micro: ACR 30–299 mg/g; macro: ACR≥300 mg/g) was assessed from spot urine at all study visits. In a sub-analysis, we included only non-deceased participants with complete attendance and valid ACR measures at all study visits.
Results
At baseline, mean age was 80.4 years (range: 70–100) and 52.6% were females. Median ACR increased from 10.7 at baseline to 13.3 mg/g after 8 years. Prevalence of micro- and macroalbuminuria remained nearly stable over time (21.6–25.3% and 3.3–4.1%, respectively). In the subgroup with complete attendance, median ACR raised from 7.3 to 13.2 mg/g, whereas prevalence of micro- and macroalbuminuria increased from 14.9 to 25.6% and 1.7 to 3.3% after 8 years, respectively.
Conclusion
We found that over the observation period of 8 years, ACR increased longitudinally in the subgroup with complete attendance only slightly by about 6 mg/g and prevalence of microalbuminuria by 11%. Cross-sectionally, ACR increased in the total population by only 3 mg/g and prevalence of micro-and macroalbuminuria remained nearly stable over 8 years at approximately 25% and 4%, respectively. The coefficient of variation for ACR measurement is known to be relatively high, therefore values should be considered as rough estimates only.