Abstract: SA-PO381
Impact of the Platelet Distribution Width on Mortality and Cardiovascular Events in ESKD Patients
Session Information
- Hemodialysis and Frequent Dialysis: CV and Risk Prediction
November 05, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 701 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Song, Young Woo, Catholic University of Korea Incheon Saint Mary's Hospital, Incheon, Incheon, Korea (the Republic of)
- Shin, Seok Joon, Catholic University of Korea Incheon Saint Mary's Hospital, Incheon, Incheon, Korea (the Republic of)
- Eum, Sang Hun, Catholic University of Korea Incheon Saint Mary's Hospital, Incheon, Incheon, Korea (the Republic of)
- Lee, Joo Eun, Catholic University of Korea Incheon Saint Mary's Hospital, Incheon, Incheon, Korea (the Republic of)
- Park, Jin Ah, Catholic University of Korea Incheon Saint Mary's Hospital, Incheon, Incheon, Korea (the Republic of)
- Yoon, Hye Eun, Catholic University of Korea Incheon Saint Mary's Hospital, Incheon, Incheon, Korea (the Republic of)
- Lee, Yeonhee, Catholic University of Korea Incheon Saint Mary's Hospital, Incheon, Incheon, Korea (the Republic of)
Background
Platelet distribution width (PDW) was known to a risk factor and an indicator of a variety of diseases. We evaluated impact of PDW on the all-cause mortality and cardiovascular(CV) event in end-stage kidney disease (ESKD) patients who started dialysis.
Methods
The medical records of 386 ESKD patients who started maintenance dialysis between January 2006 and July 2017 were reviewed. Patients were divided into three groups; low, median and high groups based on the tertile PDW value. The primary outcome was a comparison of all-cause mortality and CV events among the PDW tertile groups. The secondary outcome is the possibility of PDW as an independent risk factor for all-cause mortality and CV event.
Results
Overall death event was 83 cases; 17 in the low PDW group, 13 in the median PDW group, and 53 in the high PDW group. CV event was 110 cases; 20 in the low PDW group, 34 in the median PDW group, and 56 in the high PDW group. The all-cause mortality was significantly higher in the high PDW group compared to the low PDW group (40.2% vs. 14.5%, P = 0.012). The CV event rate was also higher in the high PDW group compared to the low PDW group (42.4% vs. 17.1%, P = 0.027). In multivariate Cox regression analysis, high PDW was an independent predictor for all cause death before adjustment(HR 1.138, 95% CI, 1.062-1.220; P=0.000), and even after adjustment for age, smoking, diabetes, body mass index, C-reactive protein, and previous CV disease (HR 1.120, 95% CI, 1.035-1.213; P=0.005).
Conclusion
PDW value at the time of initiating dialysis in the ESKD patients may be a simple and useful method for predicting all-cause mortality and CV event.