Abstract: FR-PO587
Serum Sulfatide Level as a Marker for Differentiation and Activity Assessment in Renal Vasculitis Diseases
Session Information
- Glomerular Diseases: Lupus and Vasculitis
November 04, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1302 Glomerular Diseases: Immunology and Inflammation
Authors
- Aomura, Daiki, Shinshu Daigaku Igakubu Fuzoku Byoin, Matsumoto, Nagano, Japan
- Harada, Makoto, Shinshu Daigaku Igakubu Fuzoku Byoin, Matsumoto, Nagano, Japan
- Nimura, Takayuki, Shinshu Daigaku Igakubu Fuzoku Byoin, Matsumoto, Nagano, Japan
- Yamada, Yosuke, Shinshu Daigaku Igakubu Fuzoku Byoin, Matsumoto, Nagano, Japan
- Hashimoto, Koji, Shinshu Daigaku Igakubu Fuzoku Byoin, Matsumoto, Nagano, Japan
- Kamijo, Yuji, Shinshu Daigaku Igakubu Fuzoku Byoin, Matsumoto, Nagano, Japan
Group or Team Name
- Department of Nephrology at Shinshu University school of medicine
Background
Sulfatides are glycosphingolipids associated with coagulation and platelet aggregation, suggesting a possible involvement in renal vasculitis (RV). However, research on this notion is extremely limited, with only one study on a small population of healthy individuals and patients with ANCA-associated vasculitis (AAV) revealing serum sulfatide (SS) level as a possible differentiation marker in AAV, especially with active crescentic findings on kidney biopsy. To further assess the association between SS and RV, we performed a retrospective study with a larger sample size including several RV diseases.
Methods
This cross-sectional investigation included patients admitted to the Nephrology Department of Shinshu University Hospital (Japan) after April 2008. Patients who were firstly diagnosed as having IgA vasculitis (IgAV), AAV, or anti-GBM disease (GBM) were included. As controls, donor candidates for living kidney transplantation (donors) were analyzed as well. SS levels were analyzed using stored frozen serum samples.
Results
The mean±standard deviation SS levels of donors (n=23), IgAV (n=26), AAV (n=64), and GBM (n=10) were 8.30±1.68, 6.14±1.59, 5.30±2.02, and 2.72±0.94 nmol/mL, respectively. Regarding associations with kidney biopsy findings, SS levels were significantly higher in patients with a higher crescentic score (Oxford classification) in IgAV. In contrast, SS levels were significantly lower in patients with a crescent-type phenotype (Berden classification) in AAV and negatively correlated with the percentage of glomeruli with cellular crescents in GBM (r=-0.76, p=0.02). Those associations of active pathological findings with SS level were stronger than with other possible markers including serum C-reactive protein level in all RV groups.
Conclusion
SS level is a possible marker for differentiation and activity assessment in RV diseases.