Abstract: TH-PO797
Effect of Structured Exercise on Biomarkers of Kidney Health in Sedentary Older Adults in the LIFE Study: A Randomized Clinical Trial
Session Information
- Voices, Choices, and Outcomes of Older Adults with CKD
November 03, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
Abstract Time: 10:00 AM - 12:00 PM
Category: Geriatric Nephrology
- 1200 Geriatric Nephrology
Authors
- Sheshadri, Anoop, University of California San Francisco, San Francisco, California, United States
- Lai, Mason, University of California San Francisco, San Francisco, California, United States
- Hsu, Fang-Chi, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States
- Bauer, Scott R., University of California San Francisco, San Francisco, California, United States
- Chen, Shyh-Huei, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States
- Jotwani, Vasantha, University of California San Francisco, San Francisco, California, United States
- Tranah, Gregory J., California Pacific Medical Center, San Francisco, California, United States
- Fielding, Roger A., Tufts Medical Center, Boston, Massachusetts, United States
- Liu, Christine, Stanford University School of Medicine, Stanford, California, United States
- Ix, Joachim H., University of California San Diego, La Jolla, California, United States
- Coca, Steven G., Icahn School of Medicine at Mount Sinai, New York, New York, United States
- Shlipak, Michael, University of California San Francisco, San Francisco, California, United States
Group or Team Name
- LIFE-Kidney Investigators
Background
We previously demonstrated among older adults that a structured exercise intervention slowed kidney function decline over two years, independently of changes in blood pressures and weight. In an ancillary study to the Lifestyle Interventions and independence For Elders (LIFE) study, we sought to evaluate mechanisms by which physical activity and exercise might slow kidney decline using biomarkers of kidney health.
Methods
Participants in LIFE were 1381 sedentary adults aged 70-89 years who were randomized to a structured exercise intervention or health education (HE). Physical activity was measured by step count (Actigraph wGT3X-B). Blood and urine samples were collected at baseline, year 1 and year 2 of follow-up. We estimated the association of step count and biomarkers of kidney health using mixed effects models. Primary outcomes were changes in 14 blood and urine biomarkers of kidney health categorized by quartiles to allow for comparisons across biomarkers.
Results
Participants assigned to the intervention walked a mean 291 more steps/day compared to HE. The intervention was not significantly associated with changes in any biomarkers. However, persons in the highest versus lowest quartile of steps (≥3470 vs. <1568 steps) had statistically significant improvement in biomarkers assessing for glomerular injury, tubular function and repair, tubular injury, generalized inflammation, and tubulointerstitial fibrosis. (Figure).
Conclusion
While randomization to a structured exercise program did not result in improvements in biomarkers at a group level, larger increases in step count were associated with improvements in several biomarkers of kidney health.
Funding
- NIDDK Support