Kidney Week

Abstract: SA-PO700

Synergistic Effect of Proteinuria on Hematuria-Related Decline in Kidney Function: The Japan Specific Health Checkups (J-SHC) Study

Session Information

• Glomerular Diseases: Clinical, Outcomes, Trials - III
  November 05, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
  Abstract Time: 10:00 AM - 12:00 PM

Category: Glomerular Diseases

• 1303 Glomerular Diseases: Clinical‚ Outcomes‚ and Trials

Authors

• Tasaki, Hikari, Nara Kenritsu Ika Daigaku, Kashihara, Nara, Japan

Hikari Tasaki,

• Eriguchi, Masahiro, Nara Kenritsu Ika Daigaku, Kashihara, Nara, Japan

Masahiro Eriguchi,

• Yoshida, Hisako, Osaka Koritsu Daigaku Igakubu Daigakuin Igaku Kenkyuka, Osaka, Osaka, Japan

Hisako Yoshida,

• Uemura, Takayuki, Nara Kenritsu Ika Daigaku, Kashihara, Nara, Japan

Takayuki Uemura,

• Nishimoto, Masatoshi, Nara Kenritsu Ika Daigaku, Kashihara, Nara, Japan

Masatoshi Nishimoto,

• Kosugi, Takaaki, Nara Kenritsu Ika Daigaku, Kashihara, Nara, Japan

Takaaki Kosugi,

• Matsui, Masaru, Nara-ken Sogo Iryo Center, Nara, Nara, Japan

Masaru Matsui,

• Samejima, Ken-ichi, Nara Kenritsu Ika Daigaku, Kashihara, Nara, Japan

Ken-ichi Samejima,

• Kasahara, Masato, Steering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease (CKD) Based on the Individual Risk Assessment by Specific Health Check, Fukushima, Fukushima, Japan

Masato Kasahara,

• Iseki, Kunitoshi, Steering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease (CKD) Based on the Individual Risk Assessment by Specific Health Check, Fukushima, Fukushima, Japan

Kunitoshi Iseki,

• Asahi, Koichi, Steering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease (CKD) Based on the Individual Risk Assessment by Specific Health Check, Fukushima, Fukushima, Japan

Koichi Asahi,

• Yamagata, Kunihiro, Steering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease (CKD) Based on the Individual Risk Assessment by Specific Health Check, Fukushima, Fukushima, Japan

Kunihiro Yamagata,

• Konta, Tsuneo, Steering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease (CKD) Based on the Individual Risk Assessment by Specific Health Check, Fukushima, Fukushima, Japan

Tsuneo Konta,

• Fujimoto, Shouichi, Steering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease (CKD) Based on the Individual Risk Assessment by Specific Health Check, Fukushima, Fukushima, Japan

Shouichi Fujimoto,

• Narita, Ichiei, Steering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease (CKD) Based on the Individual Risk Assessment by Specific Health Check, Fukushima, Fukushima, Japan

Ichiei Narita,

• Shibagaki, Yugo, Steering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease (CKD) Based on the Individual Risk Assessment by Specific Health Check, Fukushima, Fukushima, Japan

Yugo Shibagaki,

• Moriyama, Toshiki, Steering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease (CKD) Based on the Individual Risk Assessment by Specific Health Check, Fukushima, Fukushima, Japan

Toshiki Moriyama,

• Watanabe, Tsuyoshi, Steering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease (CKD) Based on the Individual Risk Assessment by Specific Health Check, Fukushima, Fukushima, Japan

Tsuyoshi Watanabe,

• Tsuruya, Kazuhiko, Nara Kenritsu Ika Daigaku, Kashihara, Nara, Japan

Kazuhiko Tsuruya,

Background

We hypothesized that proteinuria had an effect modification on hematuria-related kidney function decline.

Methods

This is a longitudinal observational study. Participants was 40 to 74 years old and those who received multiple nationwide specific health checks between 2008 and 2014. The exposures of interest were hematuria (presence or absence) and proteinuria (3 categories: none, occasional, and persistent). Using a mixed-effects model, trajectories of eGFR decline adjusted for clinically relevant factors were examined between hematuria categories stratified by proteinuria categories.

Results

Among 552,951 subjects, 146,753 (26.5%) had hematuria, and 56,021 (10.1%) and 8,061 (1.5%) had occasional and persistent proteinuria, respectively. During the median follow up of 3.0 years, annual change in eGFR decline in participants with hematuria (median [95% confidence interval]: −0.95 [−0.98 to −0.92] mL/min/1.73 m²/year) was significantly faster than those without hematuria (−0.86 [−0.87 to −0.84] mL/min/1.73 m²/year, P <0.001) in the entire cohort. The differences in eGFR decline rate between participants with and without hematuria (mean ± standard error) were 0.036±0.005, 0.027±0.013, and 0.130±0.048 mL/min/1.73 m²/year in none, occasional, and persistent proteinuria categories, respectively. Proteinuria had synergistic effect on hematuria-related eGFR decline rate (P for interaction <0.001).

Conclusion

Proteinuria has a synergistic effect on the hematuria-related decline in kidney function.