Kidney Week

Abstract: TH-PO046

Serum Potassium Trajectory During AKI and Mortality

Session Information

• AKI: Biomarkers, Risk Factors, Treatments, Outcomes
  November 03, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
  Abstract Time: 10:00 AM - 12:00 PM

Category: Acute Kidney Injury

• 102 AKI: Clinical‚ Outcomes‚ and Trials

Authors

• Chavez, Jonathan, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico

Jonathan Chavez,

• Navarro Blackaller, Guillermo, Hospital Civil de Guadalajara, Guadalajara, Jalisco, Mexico

Guillermo Navarro Blackaller,

• Maggiani, Pablo, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico

Pablo Maggiani,

• Diaz Villavicencio, Bladimir, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico

Bladimir Diaz Villavicencio,

• Oliva, Ana Elisa, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico

Ana Elisa Oliva,

• de la Vega Méndez, Frida Margarita, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico

Frida Margarita de la Vega Méndez,

• Garcia-Garcia, Guillermo, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico

Guillermo Garcia-Garcia,

• Calderon Garcia, Clementina Elizabeth, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico

Clementina Elizabeth Calderon Garcia,

• Prieto Magallanes, Manuel Luis, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico

Manuel Luis Prieto Magallanes,

• Martínez Gallardo González, Alejandro, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico

Alejandro Martínez Gallardo González,

• Romero, Alexia, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico

Alexia Romero,

Background

The association between potassium (sK) trajectory and mortality or the need for kidney replacement therapy (KRT) during acute kidney injury (AKI) has not been explored

Methods

In this prospective cohort study, AKI patients were divided in 8 groups based on sK (mEq/L) trajectories, (1) normoK, sK between 3.5-5.5; (2) corrected hyperK, sK > 5.5 to normoK; (3) corrected hypoK, sK < 3.5 to normoK; (4) fluctuating potassium, sK increased / decreased in and out of normoK; (5) uncorrected hypoK, sK < 3.5; (6) normoK to hypoK, sK normal and decreased to hypoK; (7) normoK to hyperK, (8) uncorrected hyperK, sK > 5.5. We assessed the association of sK trajectories with mortality and the need for KRT

Results

In 311 AKI patients. AKI 3 was present in 63.9%. KRT started in 36%, and 21.2% died. After adjusting for confounders, 10-day hospital mortality was higher in group 7 and 8 (OR, 1.37 and 1.63 p = <0.05, respectevely), and KRT initiation was higher in group 8 (OR 1.40 p = < 0.05) compared with group 1. Mortality in different subgroups of patients did not change the primary results

Conclusion

In our prospective cohort, most patients with AKI had dyskalemia. NormoK to hyperK and Uncorrected hyperK were associated with death, while only uncorrected hyperK was correlated with the need for KRT

The association between sK+ trajectories and 10-days mortality

OR of unadjusted 10-days mortality in different subgroups of patients with
uncorrected hyperK