Abstract: PO1053
Using the Seraph® 100 Microbind® Affinity Blood Filter Under Slow Flow Conditions Through a Normal Central Line
Session Information
- Vascular Access Arena: Challenges, Progress, and Prospects
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 703 Dialysis: Vascular Access
Authors
- Seffer, Malin-Theres, Academic Teaching Hospital Braunschweig, Braunschweig, Germany
- Schmidt, Julius, Medizinische Hochschule Hannover, Hannover, Niedersachsen, Germany
- Kielstein, Jan T., Academic Teaching Hospital Braunschweig, Braunschweig, Germany
Group or Team Name
- Kielstein Lab
Background
The Seraph® 100 Microbind® Affinity blood filter has been in use since 2019 for the treatment of difficult to treat blood stream infections.and since 2020 for the treatment of critically ill COVID-19 patients. It is operated under blood flow rates of 100 – 350 mL/min, which requires a large bore central line a dialysis catheter. The aim of our study was to evaluate to evaluate the usability of the Seraph® 100 under slow flow conditions through a normal central line (in clinical practice).
Methods
A standard hemoperfusion blood tubing system as well as the Seraph® 100 (Exthera Medical, CA, USA) was used. Vascular access was a 20 cm trillumen central venous line (2 x 18 G and 1 x 16 G) that was inserted into a reservoir. The Multifiltrate (Fresenius Medical Care) was used to pump normal saline (n=5) or human plasma (n=5) through the Seraph® 100. Pressures were recored at any given flows (Qb).
In two patients connected to a five lumen 20 cm catheter (Certofix Safety Quinto S1220, B. Braun, Melsungen, Germany - 1 x 12 G, 1 x 16 G, 3 x 18 G) blood flow as well as arterial and venous pressure were recorded through the 24 h treatment.
Results
Using saline or human plasma the Seraph® 100 Microbind®Affinity Blood Filter can be operatied at blood flow rates of up to 100 mL/min even through a 16 & 18 G lumen at tolerable arterial and venous pressures. In men using either the 12 G or the 16 G lumen as "arterial line" blood a blood flow rate of 50 mL/mon could be onbtained for 24 hours without problems.
Conclusion
The Seraph® 100 Microbind®Affinity Blood Filter can be operated at blood flow rates of 50 mL/min even through 16 & 18 G catheters.
"Arterial" and "venous" pressures depending on the flow (Qb) during hemoperfusion with the Seraph® 100 Microbind®Affinity Blood Filter.