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Abstract: PO0873

Fibrosis-4 Index May Predict Mortality and Non-Fatal Cardiovascular Events in ESKD Patients Starting Dialysis

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Lee, Yeonhee, The Catholic University of Korea Incheon St. Mary''s Hospital, Incheon, Korea (the Republic of)
  • Kim, Da won, The Catholic University of Korea Incheon St. Mary''s Hospital, Incheon, Korea (the Republic of)
  • Shin, Seok Joon, The Catholic University of Korea Incheon St. Mary''s Hospital, Incheon, Korea (the Republic of)
  • Yoon, Hye Eun, The Catholic University of Korea Incheon St. Mary''s Hospital, Incheon, Korea (the Republic of)
  • Lee, Joo Eun, The Catholic University of Korea Incheon St. Mary''s Hospital, Incheon, Korea (the Republic of)
Background

CKD and ESKD are known risk factors of heart failure(HF). And liver dysfunction as congestive hepatopathy due to HF is also common. Recent studies report that Fibrosis-4(FIB4) index(age×AST(IU/L)/platelet count(103/uL)×square root of ALT(IU/L)), which was known to be useful tool for evaluating liver stiffness, can be prognostic factor of HF. Therefore, this study investigated whether FIB4 index may predict mortality and cardiovascular events(CVE) in patients with ESKD starting dialysis.

Methods

This was a retrospective cohort study including 388 patients who started dialysis at a single center. FIB4 index at dialysis initiation was calculated. Patients were stratified into three groups according to FIB4 index(<1.45:low, 1.45~3.25:intermediate, >3.25: high). The association between FIB4 index and event free survival rates for all-cause mortality and non-fatal CVE was analyzed. In addition, the association between FIB4 index and echocardiographic findings was analyzed.

Results

During a median follow-up duration of 40.0(0.03-142.3) months, 84 deaths(21.6%) and 83 non-fatal CVE(21.4%) occured. Event free survival rates were lower in high-FIB4 group, compared with those in low-FIB4 group(p=0.001) and intermediate-FIB4 group(p=0.005), respectively. In Cox proportional hazard model, the high FIB4 index was independently associated with event free survival rates(HR, 2.21; 95% CI, 1.17-4.18; p=0.015). When comparing echo findings, only left atrial diameter(LAD) showed difference among groups(p=0.033). However, there was no significant correlation between LAD and FIB4 index.

Conclusion

In conclusion, FIB4 index is associated with event free survival rates for all cause mortality and non-fatal CVE in ESKD patients starting dialysis.