Abstract: TH-PO602
Association of Inflammation with Dynapenia and Sarcopenia in Hemodialysis Patients: A Pilot Observational Study
Session Information
- Health Maintenance, Nutrition, Metabolism - I
November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1300 Health Maintenance, Nutrition, and Metabolism
Authors
- Kumar, Rajesh B., Apex Kidney Care, Mumbai, India
- Jasani, Rachana H., Apex Kidney Care, Mumbai, India
- Dedhia, Paras, Apex Kidney Care, Mumbai, India
- Billa, Viswanath, Bombay Hospital, Mumbai, India
- Bichu, Shrirang, Bombay Hospital, Mumbai, India
- Kothari, J., Hinduja Hospital,Healthcare & Apex Kidney Foundation, Mumbai, India
- Mohd shah, Alam, Apex Kidney Care, Mumbai, India
- Gupta, Virendra, Apex Kidney Care, Mumbai, India
Group or Team Name
- Apex Kidney Care
Background
Chronic inflammation is directly related to an increased cardiovascular mortality in hemodialysis patients. Low muscle strength (dynapenia) and low muscle strength in addition to decreased skeletal muscle mass (sarcopenia) often coexist with obesity in chronic hemodialysis patients. The main aim was to study the association of inflammation with sarcopenic obesity (SO) and dynapenic obesity (DO) in chronic hemodialysis patients.
Methods
High sensitivity C-reactive protein (hs CRP) was estimated using Nephelometry. hsCRP >10 mg/L was considered positive for inflammation. Body Composition Analysis through bioelectrical impedence was utilized to assess body fat and lean tissue index (LTI). Muscle strength was determined using handgrip strength (HGS) analysis. Dynapenia was defined by HGS <26 kg for men and < 18 kg for women. Sarcopenia was defined as LTI <10.7 kg/m2 in men and <6.7 kg/m2 in women. Obesity was defined as percent body fat > 25% in men and > 35% in women. Prevalence of inflammation in patients with DO and SO was reported.
Results
Of 81 patients, 49 were males. Their average age was 56.9± 16.1 years and average dialysis vintage was 2.9±2.4 years. All patients were on thrice a week hemodialysis. The etiology of kidney disease was diabetic kidney disease in 49%, hypertension in 31%, chronic tubulo interstitial disease in 7%, chronic glomerulonephritis in 4% and others in 9% patients. Mean hsCRP of was 12.4±11.9 mg/L. The overall prevalence of DO was 20.9% and SO was 16%. The prevalence of inflammation in patients with DO was 52.9% and without DO was 47.0%. The prevalence of inflammation in patients with SO was 46.1% and without SO was 37.1%. The prevalence of inflammation in diabetic patients with DO was 66.5% and that in diabetic patients with SO was 59.8%.
Conclusion
The prevalence of inflammation was higher in patients with both DO as well as SO, especially in diabetic population. Further long term studies are needed to assess the relationship between DO, SO and inflammation and their outcomes in hemodialysis population.