Abstract: PUB328
Adiponectin Influences Skeletal Muscle Mass in Renal Transplant Recipients
Session Information
Category: Transplantation
- 1902 Transplantation: Clinical
Authors
- Adachi, Hiroki, Kanazawa Medical University, Uchinada, Japan
- Fujimoto, Keiji, Kanazawa Medical University, Uchinada, Japan
- Miyatake, Nobuhiko, Kanazawa Medical University, Uchinada, Japan
- Okada, Keiichiro, Kanazawa Medical University, Uchinada, Japan
- Okino, Kazuaki, Kanazawa Medical University, Uchinada, Japan
- Furuichi, Kengo, Kanazawa Medical University, Uchinada, Japan
- Yokoyama, Hitoshi, Kanazawa Medical University, Uchinada, Japan
Background
The sarcopenia in chronic kidney disease is an important issue, however. The long-term association between skeletal muscle mass and serum adiponectin (ADPN) after renal transplantation (RTX) has not been investigated.
Methods
A retrospective survey of 51 patients who received renal transplantation at our hospital after 1998 (living donor: 40, cadaveric kidney: 11, 31 males and 20 females) was performed．The associations with the psoas muscle index (PMI), intramuscular adipose tissue (IMAC), and serum high molecular weight (HMW) - ADPN were investigated over time. In addition, the association of post-transplant diabetes mellitus (PTDM) with PMI and IMAC was investigated.
Results
The age at the time of transplantation was inversely correlated with PMI before RTX and positively correlated with IMAC before RTX (rS=-0.427, p=0.002; rS=0.501, p=0.001, respectively). Compared with that before RTX, PMI gradually increased after RTX (p<0.01). On the other hand, IMAC decreased at 1 year after RTX and then re-increased at 5 year after RTX (p<0.05). Moreover, the increase of the mean change of PMI after RTX was significantly influenced by the increasing mean change of HMW-ADPN levels on the multivariate analysis (beta=-0.140, p=0.003). Otherwise, the increases in the mean change of PMI and IMAC were detected as provocative factors of PTDM (beta=1.574, p=0.030 and beta=172.5, p=0.034, respectively).
Conclusion
In renal transplant recipients, sarcopenia judged by the mass and quality of psoas muscles after RTX may be associated with the alteration of serum HMW-ADPN levels and PTDM.
Funding
- Government Support - Non-U.S.