Abstract: SA-PO904
Investigation of Concentration of Blood Solubilized CD40 Ligand (sCD40L) in Maintenance Dialysis Patients
Session Information
- Dialysis: Cardiovascular, BP, Volume
October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 701 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Karube, Miho, Kyorin University School of Medicine, Tokyo, Japan
- Kaname, Shinya, Kyorin University School of Medicine, Tokyo, Japan
Background
The soluble CD40 ligand (sCD40L), one of the factors released from activated platelets, has been recently suggested to relate to the pathogenesis of atherothrombotic events for a possible biomarker predicting cardiovascular outcomes. Thus, we examined the sCD40L levels in patients on maintenance dialysis.
Methods
The 15 patients undergoing maintenance dialysis in our hospital were enrolled after informed consents. The sCD40L levels before hemodialysis, 1 hour and 4 hours after initiation of hemodialysis were measured by enzyme-linked immunosorbent assays.
Results
The mean concentration of sCD40L before dialysis was 221.3 pg/ml, higher than that 34.3 pg/ml in healthy controls (n=3). The sCD40L levels were positively correlated with platelet counts and appeared to be higher in patients with a long duration of hemodialysis. The kinetics of sCD40L during hemodialysis showed that the concentrations increased to 271.0 pg/ml after 1 hour and decreased to 160.2 pg/ml after 4 hours, suggesting 30% of removal by hemodialysis. The rate of an increase during the first one hour were greater in diabetic patients (n=7) than that in non-diabetic patients (n=8). The average removal rate was 27.6%, with no differences among various types of dialyzers.
Conclusion
The sCD40L levels in hemodialysis patients are higher, although partially removed by dialysis, as compared to healthy people, and might be associated with an increased risk of atherosclerosis possibly through the platelet activation.