Kidney Week

Abstract: SA-PO896

Involvements of AGEs on Vascular Calcification in Hemodialysis Patients

Session Information

• Dialysis: Cardiovascular, BP, Volume
  October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Dialysis

• 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

• Nagasawa, Hajime, Juntendo University Faculty of Medicine, TOKYO, Japan

Hajime Nagasawa,

• Ueda, Seiji, Juntendo University Faculty of Medicine, TOKYO, Japan

Seiji Ueda,

• Kobayashi, Takashi, Juntendo University Faculty of Medicine, TOKYO, Japan

Takashi Kobayashi,

• Kanaguchi, Yasuhiko, Juntendo University Faculty of Medicine, TOKYO, Japan

Yasuhiko Kanaguchi,

• Yamagishi, Sho-ichi, Kurume University Faculty of Medicine, Kurume, FUKUOKA, Japan

Sho-ichi Yamagishi,

• Suzuki, Yusuke, Juntendo University Faculty of Medicine, TOKYO, Japan

Yusuke Suzuki,

Background

Vascular calcification is one of the strong risk factors for cardiovascular events and mortality in chronic kidney disease (CKD) patients. Advanced glycation end products (AGEs) are known to be accumulated in diabetes and/ or CKD patients and contributing to the development of vascular complications such as the arteriosclerosis and vascular calcification. However, the mechanisms why and how AGEs are increased in patients with hemodialysis and its precise roles on the development of vascular calcification are remained to be elucidated.

Methods

To address this issue, we investigate the relationship among the serum levels of AGEs and metabolic factors in 37 chronic hemodialysis patients in our hospital. We also evaluated the relationship between AGEs levels and vascular calcification assessed by agaston score and abdominal aorta calcification score (ACI) in the abdominal CT.

Results

Serum AGEs levels are significantly associated with not only age, presence of diabetes and peripheral artery disease (PAD), geriatric nutritional risk index (GNRI), and inflammatory markers such as IL-6, TNF-alpha but also agaston score and ACI. Moreover, retrospective analysis reveals that annual increasing rates of vascular calcification score are tended to be associated with AGEs in addition to age, presence of diabetes, and TNF-alpha levels.

Conclusion

These observations strongly suggest that chronic inflammatory responses may be involved in AGEs formation in chronic hemodialysis patients and accumulated AGEs may contribute to the development of vascular calcification and cardiovascular disease such as PAD.