Kidney Week

Abstract: SA-PO693

Relationship Between Bioelectrical Impedance Body Composition and CKD-MBD in Dialysis Patients

Session Information

• Bone and Mineral Metabolism: Clinical - II
  October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Bone and Mineral Metabolism

• 402 Bone and Mineral Metabolism: Clinical

Authors

• de Sa Carneiro Filho, Eduardo J. D., Universidade de Sao Paulo, Sao Paulo, Brazil

Eduardo J. D. de Sa Carneiro Filho,

• Crispilho, Shirley Ferraz, Universidade Nove de Julho, São Paulo, Brazil

Shirley Ferraz Crispilho,

• Cordeiro, Lilian, Universidade de Sao Paulo, Sao Paulo, Brazil

Lilian Cordeiro,

• Dalboni, Maria, Universidade Nove de Julho, São Paulo, Brazil

Maria Dalboni,

• Elias, Rosilene M., Universidade de Sao Paulo, Sao Paulo, Brazil

Rosilene M. Elias,

• Moyses, Rosa M.A., Universidade de Sao Paulo, Sao Paulo, Brazil

Rosa M.A. Moyses,

Background

Recent studies have assessed body composition through multifrequency bioelectrical impedance analysis (MF-BIA). However, none has employed this technique to test the associations of CKD-MBD with body composition. As recent experimental studies have linked hyperparathyroidism with an increase in energy expenditure, it is important to validate this hypothesis in a clinical scenario.

Methods

In a transversal study, we evaluated 160 prevalent dialysis patients (hemodialysis, HD = 99; peritoneal dialysis, PD = 61) through whole-body and segmental composition and correlated MF-BIA with CKD-MBD parameters.

Results

Patients were 49 years old (range 18-90), with BMI = 24.6 kg/m² (13.3-49.3), fat mass (FAT) = 17.8 kg (1.1-61.5), muscular mass (MUSC) = 25.6 kg (10.1-45.4), bone mineral content (BMC) = 2.78 kg (2.43-3.30). In PD patients, serum 25 vitamin D correlated with MUSC (r= 0.41 p = 0.002) and BMC (r = 0.42 p =0.002). Alkaline phosphatase correlated negatively with FAT (r = - 0.30. p 0.02). No significant correlations were found for parathormone, calcium, phosphate or albumin. In HD patients, we did not find any significant correlation between MF-BIA and CKD-MBD parameters.

Conclusion

Assuming the accuracy of MF-BIA, in PD patients, higher serum vitamin D levels were associated with lower risk of sarcopenia and low bone mineral density, whereas higher alkaline phosphatase was linked with lower fat mass. Future prospective studies should evaluate whether cholecalciferol supplementation and hyperparathyroidism control could improve muscle, bone and fat masses in these patients.

Funding

• Government Support - Non-U.S.