Kidney Week

Abstract: SA-PO681

Vascular Calcifications in Patients with Calcium and Uric Acid Kidney Stone Composition

Session Information

• Bone and Mineral Metabolism: Clinical - II
  October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Bone and Mineral Metabolism

• 402 Bone and Mineral Metabolism: Clinical

Authors

• Ferraro, Pietro Manuel, Fondazione Policlinico Universitario A. Gemelli, Rome, Rome, Italy

Pietro Manuel Ferraro,

• Marano, Riccardo, Polyclinic Foundation A. Gemelli IRCCS - Catholic University, Rome, Italy

Riccardo Marano,

• Primiano, Aniello, Istituto di Biochimica e Biochimica Clinica Università Cattolica del Sacro Cuore, Rome, Italy

Aniello Primiano,

• Gervasoni, Jacopo, Area Diagnostica di Laboratorio IRCCS Fondazione Policlinico Universitario A. Gemelli, Rome, Italy

Jacopo Gervasoni,

• Gambaro, Giovanni, Fondazione Policlinico Universitario A. Gemelli, Rome, Rome, Italy

Giovanni Gambaro,

Background

Kidney stone disease has been associated with incident cardiovascular events, as well as with vascular calcifications. It is not known whether the likelihood and extent of vascular calcifications differ in patients with different types of stone composition.

Methods

We retrospectively evaluated CT scan images of patients who underwent at least one kidney stone composition analysis during the 2015-2018 period. Kidney stones were analyzed by Fourier-transform infrared spectroscopy and categorized as follows: calcium stones (≥50% calcium oxalate or calcium phosphate), uric acid stones (any uric acid).
A calcification score was calculated from the CT scan images at the abdominal aorta and expressed as calcium volume. The radiologist who performed the calcification score evaluation was not aware of the stone composition group of the patients.
For patients who underwent multiple kidney stone composition analyses and/or CT scans, information on vascular calcification was obtained from the CT scan closest in time to a kidney stone composition analysis.

Results

We enrolled 30 patients with at least one kidney stone composition analysis in the observation period who had undergone at least one CT scan examination at our Institution. Average age was 56±16 years, 16 (53%) were males. Patients with uric acid stones had significantly higher values of calcification at abdominal aorta (975 mm³, 95% CI −3, 1,953 mm³; p=0.05). However, such differences attenuated after adjustment for age (370 mm³, 95% CI −598, 1,337 mm³; p=0.44).

Conclusion

Patients who form uric acid stones seem to have worse calcifications at abdominal aorta compared with those who form calcium stones; however, this association could be at least in part mediated by differences in age between groups.