Abstract: SA-PO086
Effects of Age and Body Mass Index on Enlargement of the Remaining Kidney in Living Kidney Transplant Donors
Session Information
- Transplantation: Recipient and Donor Assessment
October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 1802 Transplantation: Clinical
Author
- Tsujita, Makoto, Nagoya Daini Red Cross Hospital, Nagoya, Japan
Background
In living kidney transplant donors, recent studies have reported some problems related to long term safety of living kidney donations. After nephrectomy, compensatory hypertrophy of the remaining kidney occurs to recover kidney function. To know how large it would be is very informative. However, factors that affect compensatory hypertrophy remain unknown.
Methods
Kidney volumes were measured using computed tomography volumetry before donation and one year after kidney donation in continuous 83 living kidney transplant donors from 2014 to 2015 at Nagoya Daini Red Cross Hospital, Japan. Ratio of kidney volume before donation and one year after donation was measured. Factors such as age, body mass index (BMI), estimated glomerular filtration rate (eGFR), blood pressure (BP) and so on which could affect the ratio were evaluated. Selection of kidney transplant donors was done according to the guideline set by the Japanese Society of Transplantation.
Results
Thirty-seven donors among all kidney donors evaluated in the study were men. Mean age before donation was 57.0 ± 10.7 years. eGFR before donation was associated with kidney volume (r=0.24 p=0.04). Age had a negative correlation with the ratio (r=0.40, p<0.001), but BMI and eGFR had a positive correlation respectively (r=0.21 p=0.05, r=0.24 p=0.04, respectively). However, the difference in eGFR before donation and one year after donation was not associate with the ratio. Multivariate analysis showed that age and BMI had strong association with the ratio.
Conclusion
Age and BMI were associated with compensatory renal hypertrophy. These factors would be taken more into consideration in the selection of living kidney transplant donors.