Abstract: SA-PO891
Association Between Coronary Artery Calcification Density and Serum Magnesium Levels in Maintenance Hemodialysis (MHD) Patients
Session Information
- Dialysis: Cardiovascular, BP, Volume
October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 701 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Nishizawa, Yoshiko, Ichiyokai Harada Hospital, Hiroshima-shi, HIROSHIMA, Japan
- Mizuiri, Sonoo, Ichiyokai Harada Hospital, Hiroshima-shi, HIROSHIMA, Japan
- Ono, Kyoka, Ichiyokai Harada Hospital, Hiroshima-shi, HIROSHIMA, Japan
- Yamashita, Kazuomi, Ichiyokai Harada Hospital, Hiroshima-shi, HIROSHIMA, Japan
- Shigemoto, Kenichiro, Ichiyokai Harada Hospital, Hiroshima-shi, HIROSHIMA, Japan
- Masaki, Takao, Division of Nephrology, Hiroshima, Japan
Background
Coronary artery calcification score (CACS) is determined by the plaque area and density. In general population, calcified plaques with lower density are associated with higher risk of incident cardiovascular events, but report on calcification density in hemodialysis patients was scanty. This study aimed to analyze the association between coronary artery calcification density (CACD) and clinical parameters in MHD patients.
Methods
Methods: The subjects were 289 Japanese MHD patients. Total calcified area (area), CACD, CACS, laboratory parameters, and medication use were studied at baseline. The subjects were stratified into CACD level tertiles (T1–T3) and assessed by Kruskal-Wallis test. Regression analyses for CACD and CACS were examined, respectively. Independent variables were age, sex, diabetes, CVD, serum magnesium, phosphate, uric acid, C-reactive protein (CRP), low-density lipoprotein cholesterol (LDL-C) levels and use of proton pump inhibitors (PPI) or sevelamer hydrochloride. Spearman’s correlations of the area and CACS or CACD were also analyzed, respectively.
Results
Among all patients, the mean age was 65±13 years, 37.2% were diabetics, and the median dialysis vintage was 72±99 months. The values of CACD of T1 (n=96), T2 (n=96), and T3 (n=97), were 3.61<, 3.62-3.89, and >3.90, respectively. The patients in T3 exhibited significantly higher serum magnesium, serum CRP and LDL-C levels (P<0.05). Multivariate regression analysis for CACD showed that age, diabetes, CVD [β 0.13, 95% confidence interval (CI) 0.00-0.12], and serum magnesium level [β 0.12, 95% CI (0.00-0.13)] were significantly related factors (P<0.05).While, multivariate regression analysis for CACS showed that age, diabetes, CVD [β 0.13, 95% CI 0.00-0.13], serum phosphate level [β 0.13, 95% CI (0.01-0.22)] were significantly related factors (P<0.05). CACS was correlated with total area (r = 013, P < 0.05), but the correlation between CACD and total area was not significant (r = 013, P=0.07 ).
Conclusion
CACD was significantly associated with serum magnesium levels, while CACS was significantly associated with serum phosphate levels in MHD patients. This may have a distinct clinical implication especially for coronary events.