Kidney Week

Abstract: SA-PO1047

Diet and Renal Function in the ELSA-Brasil Cohort: A Mediation Analysis

Session Information

• Diet and Nutrition: Clinical
  October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Health Maintenance, Nutrition, and Metabolism

• 1302 Health Maintenance, Nutrition, and Metabolism: Clinical

Authors

• Silva Junior, Geraldo B., University of Fortaleza, Fortaleza, Brazil

Geraldo B. Silva Junior,

• Fagundes xavier, Rosa malena, Federal University of Bahia, Salvador, Brazil

Rosa malena Fagundes xavier,

• Aquino, Estela, Federal University of Bahia, Salvador, Brazil

Estela Aquino,

• Cardoso, Leticia, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil

Leticia Cardoso,

• Salani mota, Rosa maria, Federal University of Ceara, Fortaleza, Brazil

Rosa maria Salani mota,

• Lopes, Antonio alberto, Federal University of Bahia, Salvador, Brazil

Antonio alberto Lopes,

• Mill, José geraldo, Federal University of Espirito Santo, Vitoria, Brazil

José geraldo Mill,

• Bisi molina, Maria del carmen, Federal University of Espirito Santo, Vitoria, Brazil

Maria del carmen Bisi molina,

• Barreto, Sandhi, Federal University of Minas Gerais, Belo Horizonte, Brazil

Sandhi Barreto,

• Chor, Dora, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil

Dora Chor,

• Teles santos, Carlos, Federal University of Bahia, Salvador, Brazil

Carlos Teles santos,

• Lotufo, Paulo, University of Sao Paulo, Sao Paulo, Brazil

Paulo Lotufo,

• Alvim matos, Sheila, Federal University of Bahia, Salvador, Brazil

Sheila Alvim matos,

Background

Previous studies suggest the influence of diet on renal function. The aim of this study was to investigate the associations between diet and renal function among adults in Brazil.

Methods

The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is the largest cohort study in Latin America, with 15,105 participants from 6 cities in Brazil. We have identified 4 dietary patterns in this cohort: 1) Traditional Brazilian, 2) Low sugar/low fat, 3) Fruits and vegetables, and 4) Bakery. Renal function was based on microalbuminuria and glomerular filtration rate (GFR) estimated through CKD-EPI formula. Association between dietary patterns and renal function was investigated through mediation analysis.

Results

Participants mean age was 52±9 years, with 54% female. Dietary patterns found were: traditional (45.7%), fruits/vegetables (25.5%), bakery (24.4%), low sugar/low fat (4.3%). For men, the patterns “bakery” and “fruits and vegetables” had significant effects on GFR and microalbuminuria. The “fruits and vegetables” pattern had only indirect effect on both GFR and microalbuminuria. For women, the “bakery products” pattern presented total effect on GFR and microalbuminuria. The “fruits and vegetables” pattern had the same effect, except for also presenting direct effect on GFR without adjustment (Figure 1).

Conclusion

There is association between dietary patterns and renal function. The “bakery” diet seem to have negative effect on renal function. The “fruits and vegetables” pattern have association with renal function possible due to epidemiological reverse causality effect.

Funding

• Government Support - Non-U.S.