Kidney Week

Abstract: SA-PO082

Clinical Significance of the Kidney Donor Profile Index in Deceased Donors for Prediction of Post-Transplant Clinical Outcomes: A Multicenter Cohort Study

Session Information

• Transplantation: Recipient and Donor Assessment
  October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Transplantation

• 1802 Transplantation: Clinical

Authors

• Lee, Jong hoon, Seoul St. Mary's hospital, Seoul, Korea (the Republic of)

Jong hoon Lee,

• Park, Woo Yeong, Dongsan Medical Center, Daegu, Korea (the Republic of)

Woo Yeong Park,

• Choi, Bumsoon, Division of Nephrology, Department of Internal Medicine, Seoul, Korea (the Republic of)

Bumsoon Choi,

• Park, Cheol Whee, The Catholic University of Korea, Seoul, Korea (the Republic of)

Cheol Whee Park,

• Yang, Chul Woo, Seoul St. Mary's Hospital , Seoul, Korea (the Republic of)

Chul Woo Yang,

• Kim, Yong-Soo, The Catholic University of Korea College of Medicine, Seoul, Korea (the Republic of)

Yong-Soo Kim,

• Jin, Kyubok, Keimyung University School of Medicine, Daegu, BUSAN, Korea (the Republic of)

Kyubok Jin,

• Han, Seungyeup, Keimyung University School of Medicine, Daegu, BUSAN, Korea (the Republic of)

Seungyeup Han,

• Chung, Byung ha, Seoul St. Mary's Hospital, Seoul, Korea (the Republic of)

Byung ha Chung,

Background

We investigated whether the Kidney Donor Profile Index (KDPI) system is useful in predicting clinical outcomes in deceased donor kidney transplantation (DDKT).

Methods

Four hundred sixty-nine kidney transplant recipients (KTRs) receiving kidneys from 359 deceased donors were included in this study, which involved three transplant centers. KTRs were divided into high and low KDPI KTR groups based on the median KDPI score of 67%. We compared clinical outcomes between the high KDPI and low KDPI groups.

Results

There were no significant differences in the incidence of delayed graft function and acute rejection between high and low KDPI KTR groups. In comparison with histologic findings in allograft tissues obtained within three months from KT, the proportion of glomerulosclerosis was significantly higher in the high KDPI KTR group than in the low KDPI KTR group. With Kaplan-Meier analysis, the graft survival rate was significantly lower in the high KDPI KTR group than in the low KDPI KTR group (Log rank, P=0.017), and multivariate analysis also demonstrated that a high KDPI score was a significant risk factor for death censored allograft failure (HR 2.62, 95% CI, 1.29–5.33, P=0.008).

Conclusion

The KDPI scoring system is useful in predicting allograft outcomes in a Korean DDKT cohort.

Analysis of long-term outcome. (A) Comparison of death-censored graft survival rates between high and low KDPI KTR groups (P<0.001, Log-rank test) (B) Comparison of patient survival rates between high and low KDPI KTR groups (P=0.132, Log-rank test)