Abstract: SA-PO679
Rotating Shift Work and Kidney Stones
Session Information
- Bone and Mineral Metabolism: Clinical - II
October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Bone and Mineral Metabolism
- 402 Bone and Mineral Metabolism: Clinical
Authors
- Prochaska, Megan, Brigham and Women's Hospital, Boston, Massachusetts, United States
- Taylor, Eric N., Maine Medical Center and Tufts University School of Medicine, Portland, Maine, United States
- Curhan, Gary C., Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States
Background
Related to circadian rhythm, which is the 24-hour periodicity of physiologic processes, there is diurnal variation in excretion of urinary factors, including factors associated with kidney stone risk. Rotating shift work disrupts circadian rhythm but has not been evaluated as a risk factor for kidney stones. We examined rotating shift work with risk of incident kidney stones and 24-hour urine composition in the Nurses’ Health Study II.
Methods
We conducted a prospective analysis of 101,983 Nurses’ Health Study II participants who provided information on rotating shift work and kidney stones. We used multivariate adjusted Cox proportional hazards models to compare current (1 to 9 months, or 10 or greater months) and past rotating shift work to no rotating shift work. In a separate analysis, we used multivariate adjusted Cox proportional hazards models to compare cumulative shift work exposure to no shift work. We also analyzed rotating shift work in 24-hour urine collections from 3811 participants. We used ANOVA to compare urinary factors by rotating shift work duration.
Results
In 22 years of follow-up, there were 3,281 incident kidney stones. Compared with no rotating shift work, the multivariate adjusted relative risks for incident kidney stone were 1.16 (95% CI 0.92 to 1.46) for 1 to 9 months current rotating shift work, 1.12 (95% CI 0.92 to 1.34) for 10 months or greater current rotating shift work, and 1.12 (95% CI 1.04 to 1.20) for past rotating shift work. Compared with no rotating shift work, participants with the highest exposure of cumulative rotating shift work, 10 years or greater, the multivariate adjusted risk for incident kidney stone was 1.19 (95% CI 1.06 to 1.34). There were no substantial differences or trends in the urine composition profiles when comparing 24-hour urine collections for participants who had no rotating shift work, 1 to 4 months, 5 to 14 months, and 15 months or greater of rotating shift work during the collection period.
Conclusion
Rotating shift work was associated with a slightly higher risk of incident kidney stone compared with no rotating shift work. There were no differences in urine composition based on rotating shift work.
Funding
- NIDDK Support