Abstract: SA-PO864
Association Between Bone-Derived Biomarkers and Aortic Arch Calcification in Maintenance Hemodialysis Patients
Session Information
- Dialysis: Cardiovascular, BP, Volume
October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 701 Dialysis: Hemodialysis and Frequent Dialysis
Author
- Nitta, Kosaku, Tokyo Women's Medical University, Shinjuku-ku, ToKyo, Japan
Background
Aortic arch calcification (AoAC) is frequently detected in maintenance hemodialysis (MHD) patients and is associated with cardiovascular and all-cause mortality. We investigated the factors associated with AoAC and analyzed the relationship between bone-derived biomarkers and AoAC.
Methods
We enrolled 389 stable MHD patients. AoAC was assessed using chest-X ray examination. Demographic data was collected in addition to serum levels of biochemical and bone-derived biomarkers, including sclerostin and fibroblast growth factor 23 (FGF23).
Results
Two hundred sixteen patients (55.0%) had AoAC. Patients with AoAC score ≧ 4 were older, with a higher percentage being male, and exhibited lower serum levels of albumin and triglyceride. Serum FGF23 levels were inversely associated with AoAC severity, and FGF23was directly related to vascular calcification. Age, gender, and dialysis vintage were independent predictors of AoAC.
Conclusion
MHD patients have a high prevalence of AoAC. Levels of circulating FGF23 but not sclerostin were related to AoAC severity. Serum FGF23 levels were independently associated with AoAC.