Abstract: SA-PO894
The Relationship Between Uric Acid and New-Onset Cardio-Cerebrovascular Disease in Maintenance Hemodialysis Patients
Session Information
- Dialysis: Cardiovascular, BP, Volume
October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 701 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Wang, Wei, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China
- Li, Yuehong, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China
- Wu, Xianglan, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China
Background
Serum uric acid (SUA) has been found to be a new marker of cardiovascular risk in patients with chronic kidney disease. In hemodialysis patients, the relevant studies are rare, and the conclusions were controversial. The aim of this study was to investigate the relationship between SUA and new-onset cardio-cerebrovascular disease in maintenance hemodialysis patients.
Methods
96 maintenance hemodialysis patients who received hemodialysis more than 3 months were analyzed retrospectively between Aug. 2016 and Nov. 2017 in Beijing Tsinghua Changgung Hospital, including 66 males and 30 females. 44 (45.8%) patients had diabetes. The average age were 60.4±13.6 years (27 to 86 years old), and the average duration of dialysis was 3.0±3.5 years (6 months to 17 years). The basic characters of patients and new-onset cardio-cerebrovascular diseases during the period were recorded. Pre-dialysis laboratory tests were observed monthly. Patients were divided into two groups according to serum uric acid level as non-HUA group (155μmol/L＜female≤357μmol/l or 208μmol/l＜male≤428μmol/l), HUA group ( >357μmol/l for female or >428μmol/L for male) respectively. SPSS 20.0 software was used to analyze the relationship between serum uric acid levels and new-onset cardio-cerebrovascular disease.
Results
1. The mean pre-dialysis uric acid was 444.68±67.43umol/L, the prevalence of hyperuricemia was 68.75% (n=66). The prevalence of female (30, 100%) were significantly higher than male (36, 54.5%), P<0.01. 2. Multivariate logistic regression analysis showed that simultaneous hyperuricemia and diabetes were risk factors for new-onset cardio-cerebrovascular disease (OR=4.251, 95% CI 1.241-14.567, P=0.021). In diabetic patients, serum uric acid levels (OR=1.004, 95%CI 1.000-1.008, P=0.040) and ferritin (OR=1.022, 95% CI 1.004-1.041, P=0.017) were risk factor for new-onset cardio-cerebrovascular disease.
Conclusion
Higher serum uric acid was a risk factor for new-onset cardio-cerebrovascular disease in maintenance hemodialysis patients with diabetes.