RE: PIGN with only proteinuria? 8 hours ago

I think we are all in agreement that glomerular sub-epithelial "hump-like" deposits are non-specific having been observed in APSGN, IRGN, C3GN, DDD...

View Discussion

RE: PIGN with only proteinuria? 10 hours ago

In Primary C3GN the "intensity" of C3 staining by conventional IF is required to be greater than the intensity of IgG , IgA or IgM. The serum C3 le...

View Discussion

RE: Electrolyte Issue 10 hours ago

Vegetable proteins have a net alkaline content, whereas meat protein has a net acid content, but both proteins stimulate acid (proton) secretion in...

View Discussion

RE: Volunteer by May 7 to serve as a case report reviewer for Kidney Week 2025! 10 hours ago

If you are interested serving as a reviewer, please complete this form by May 7: https://www.asn-online.org/apply/?ID=21 Questions? Send an email...

View Discussion

RE: Volunteer by May 7 to serve as a case report reviewer for Kidney Week 2025! 10 hours ago

Hi I am a fellow in Pediatric Nephrology. I am willing to volunteer to review case reports Thank you Afsana Jahan Get Outlook for iOS The informa...

View Discussion

RE: PIGN with only proteinuria? 12 hours ago

@ prof glassock ? C3 GN would the c3 be more intensity on IF? Or are there cases where c3 is equal intensity to others and it’s is c3gn? I unders...

View Discussion

RE: Electrolyte Issue 12 hours ago

Thanks everyone really enlightening . Questions lead to discovery . I apologies for not being clever but why does vegetarian meal give rise to high...

View Discussion

RE: Electrolyte Issue 12 hours ago

As a fellow at NYU long ago, my attending Bernie Nidus, showed us his clear, pre-prandial urine, followed by a post-prandial urine: completely opaq...

View Discussion

RE: PIGN with only proteinuria? 13 hours ago

Th IF is PLA2R, sorry the label didn't show up. ------------------------------ Jonathan Zuckerman MD, PhD UCLA Los Angeles CA (310) 794-1485 ---...

View Discussion

RE: PIGN with only proteinuria? 13 hours ago

I don't disagree that the deposits appear hump-like. Rare cases of early MN can show somewhat humpy deposits. Please see attached images from a cas...

View Discussion

RE: PIGN with only proteinuria? 14 hours ago

those are HUMPS! was there only C3 on the biopsy? What was the blood C3 level? See attached ------------------------------ Ro...

View Discussion

RE: PIGN with only proteinuria? 14 hours ago

While I agree the deposits could be seen as hump-like, given the membranous pattern noted above on IF, this may be an early (stage 1) membranous ne...

View Discussion

RE: Electrolyte Issue 1 day ago

I remember being taught that the commonest cause of a urine sample with a high pH in clinical practice is a patient submitting a urine sample short...

View Discussion

RE: IVIG with Rituximab treatment 1 day ago

I agree that the general felling (not evidence based) is that IVIgG is "helpful" in some cases of ANCA Vasculitis.- unfortunately we do not know wh...

View Discussion

RE: IVIG with Rituximab treatment 1 day ago

Just one thought: while I agree that IVIG administration based on IgG level may be unwarranted, IVIG has been regarded as therapeutically helpful i...

View Discussion

RE: Electrolyte Issue 1 day ago

Many thanks for the clarification. My understanding of the "alkaline tide" has just improved. I assume that patients with atrophic gastritis (and h...

View Discussion

RE: Electrolyte Issue 1 day ago

Just a small point, but the term alkaline tide refers to the normalphysiologic response after any meal, due to the stimulation of parietal cell pro...

View Discussion

RE: PIGN with only proteinuria? 1 day ago

Setting all STI biases aside, have you ruled out secondary syphilis? --------------------------------- Oded Friedman -----------------------------...

View Discussion

RE: PIGN with only proteinuria? 1 day ago

Thanks for posting the EM. This does not seem to be APSGN or Infection related GN, so C3GN in the differential diagnosis. The pattern of C3 and C4 ...

View Discussion

RE: PIGN with only proteinuria? 1 day ago

EM deposits certainly look "humpy". Very strange case. Clinical presentation certainly suggests MCD/FSGS/podocytopathy. Will be interesting to see ...

View Discussion

RE: Volunteer by May 7 to serve as a case report reviewer for Kidney Week 2025! 1 day ago

Hello! If you are interested serving as a fellow case report reviewer, please complete this form by May 7: https://www.asn-online.org/apply/?ID=21 ...

View Discussion

RE: Volunteer by May 7 to serve as a case report reviewer for Kidney Week 2025! 1 day ago

Hello! If you are interested serving as a reviewer, please complete this form by May 7: https://www.asn-online.org/apply/?ID=21 ----------------...

View Discussion

RE: PIGN with only proteinuria? 1 day ago

attached is the EM. very curious. ------------------------------ Kenneth Brand MD West Hartford CT (860) 819-9001 ---------------------------...

View Discussion

RE: Volunteer by May 7 to serve as a case report reviewer for Kidney Week 2025! 1 day ago

Hello, i would like to volunteer as a reviewer for case reports. Please let me know further steps. Best regards, Arjun -------------...

View Discussion

RE: Volunteer by May 7 to serve as a case report reviewer for Kidney Week 2025! 1 day ago

I have done several case reports and here is my Google scholar page. I could be valuable resource for moderating case reports. https://schola...

View Discussion

RE: Case discussion 1 day ago

Thanks alot for ur valuable comments Yahoo Mail: Search, Organize, Conquer

View Discussion

RE: Case discussion 1 day ago

The main differential diagnoses are malaria (falciparum and/or vivax), G6PD deficiency and paroxysmal cold hemoglobinuria, in my Nephrological opin...

View Discussion

RE: Case discussion 1 day ago

Thanks . What are other down the list differentials ?? Yahoo Mail: Search, Organize, Conquer

View Discussion

RE: Atypical case 1 day ago

Linear monoclonal IgA deposits suggest anti-GBM Disease, but absence of crescents would be unusual. Serum anti-GBM antibodies by ELISA are often ne...

View Discussion

RE: Case discussion 1 day ago

Based on this classic presentation , this patient should be strongly suspected as having PNH. The diagnosis can be quickly affirmed by appropriate ...

View Discussion

Case discussion 1 day ago

17 years old male , hx of renal stones 8 years back, passed spontaneously in urine, no intervention required and no labs done at that timeNo other ...

View Discussion

RE: Atypical case 2 days ago

Updated the case as requested. ------------------------------ Hasan Ozpolat MD University of Arizona College of Medicine Tucson AZ (206) 393-785...

View Discussion

RE: PIGN with only proteinuria? 2 days ago

Infection related GN presenting as proteinuria only is uncommon. Could you post the de identified EM photos, so we can verify the nature of the "Hu...

View Discussion

RE: Complex SLE Case with Diffuse Alveolar Hemorrhage 2 days ago

For reasons that remain poorly understood , DAH us strongly related to anti.Phospholipid antibody . I would agree with adding RTX (or OBI , if avai...

View Discussion

PIGN with only proteinuria? 2 days ago

could turn out to be nothing special, but what i have here, folks is a 78-year-old white gentleman with sudden onset 8-10 grams of proteinuria an...

View Discussion

RE: Atypical case 2 days ago

IgA with lambda restriction is not usual and does not mean a MGRS, but that is lambda not kappa. Linear IgG is not unusual with Diabetes and is f...

View Discussion

RE: Atypical case 2 days ago

Didn’t see that coming. When will EM be available? What did pathologist conclude? LHCDD on background of DM/HTN changes? Did TBM also stain simi...

View Discussion

RE: decline in kidney function linked with Graves disease 2 days ago

Hi thanks fascinating . If the hypothesis of gfr drop causing hypothyroid would be interesting to know kidney function in hyperthyroid pre and post...

View Discussion

RE: Complex SLE Case with Diffuse Alveolar Hemorrhage 2 days ago

Thanks for the thoughtful feedback. Haptoglobin is very low, with C4 at 0.035 and C3 at 0.5 Regarding Ravulizumab, my thinking is that complement...

View Discussion

Atypical case 2 days ago

A 58-year-old female with a history of diabetes mellitus type 2 with retinopathy, uncontrolled hypertension, chronic lymphedema, and systemic lupus...

View Discussion

RE: Complex SLE Case with Diffuse Alveolar Hemorrhage 2 days ago

We had a somewhat similar patient last year, did not have alveolar hemorrhage but had a MAHA with thrombocytopenia, AKI, seizures We plexed h...

View Discussion

Complex SLE Case with Diffuse Alveolar Hemorrhage 2 days ago

I'd really love to hear your thoughts regarding this complex case. A 30‐year‐old female with a recent diagnosis of SLE (diagnosed 2 weeks prior t...

View Discussion

RE: decline in kidney function linked with Graves disease 2 days ago

"It has been my understanding that topiramate inhibits carbonic anhydrase and commonly causes a hyperchloremic acidosis and as a consequence a mode...

View Discussion

Volunteer by May 7 to serve as a case report reviewer for Kidney Week 2025! 2 days ago

ASN invites ASN Fellows-in-Training members to serve as reviewers for case reports submitted by trainees for Kidney Week 2025. The reviewing/gradin...

View Discussion

Encourage fellows to volunteer as case report reviewers for Kidney Week 2025! 2 days ago

ASN invites ASN Fellows-in-Training members to serve as reviewers for case reports submitted by trainees for Kidney Week 2025. The reviewing/gradin...

View Discussion

RE: decline in kidney function linked with Graves disease 2 days ago

It has been my understanding that topiramate inhibits carbonic anhydrase and commonly causes a hyperchloremic acidosis and as a consequence a modes...

View Discussion

RE: decline in kidney function linked with Graves disease 2 days ago

Yes Hypothyroid state can cause acute drop in the GFR-this is not reported enough and should be. I learnt this through my patient-see below. Would ...

View Discussion

RE: FSGS 2 days ago

"RASI/SGLT2i are symptomatic and do not address the pathological mechanism." That is the usual thinking, that RASIs and SGLT2is are all about remn...

View Discussion

RE: lupus nephropathy ? 2 days ago

The devil is in the details and I usually miss the devil, but for once this time no! I cannot tell you how many times I see a urea reported in mg...

View Discussion

RE: Serum sodium monitoring for starting Empagliflozin for SIADH related Hyponatremia 2 days ago

1) A baseline PNa of 131 is at essentially no risk for ODS from any increase of any kind 2) SGLT2i is a mild diuretic, and it is not an aquareti...

View Discussion