ASN represents more than 21,000 kidney health professionals working to help people with kidney diseases and their families. Comprised of all of ASN's focus areas, the ASN Alliance for Kidney Health allows the society to continue its growth and work towards the goal of a world without kidney diseases.
The latest Nephrology Self-Assessment Program (nephSAP) issue, Volume 23: Issue 2 (Jun 2024): Electrolytes and Acid-Base Disorders is now available online.
RE: IgA Vasculitis in an adult 44 minutes ago
Regarding the possibility of ANCA-associated crescentic GN superimposed on IgA nephropathy suggested by Dr. Glassock: Have you looked at any and al...
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RE: Nephrotic range proteinuria, steroid resistant FSGS ? Genetic, steroid treatment cessation 1 hour ago
Dr, Sundaramurthy: What about the thin BM abnormality - did genetic testing show COL-4 alpha-3, 4, 5 mutations also? Was the NPHS2 mutation homozyg...
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RE: Post-partum HELLP v. aHUS 4 hours ago
"I got the medication approved via our high-cost pharmacy committee overnight and am initiating eculizumab today" Congratulations, I think there ...
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RE: Post-partum HELLP v. aHUS 4 hours ago
I want to thank everyone for their incredibly helpful input. As an update, patient today remains oliguric with ongoing transfusion requiring anemia...
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RE: Nephrotic range proteinuria, steroid resistant FSGS ? Genetic, steroid treatment cessation 7 hours ago
Thanks Dr Glassock , appreciate it . --------------------------------- Dhivya Sundaramurthy MD, MBBS Des Moines IA (989) 964-9508 --------------...
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RE: IgA Vasculitis in an adult 7 hours ago
Good point Dr. Rodby- such patients usually have gross hematuria . Was this present in this case? Can you post the full pathology report (de-identi...
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RE: IgA Vasculitis in an adult 7 hours ago
2 of 10 glomeruli had crescents yet creatinine 0.92 (June '23) -> 2.23 (June '24) -> 2.98-> 3.1 RPGN with "only" 20% crescents? The AKI seems a ...
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RE: Nephrotic range proteinuria, steroid resistant FSGS ? Genetic, steroid treatment cessation 7 hours ago
My personal experience with NPHS2 mutation related FSGS and Nephrotic syndrome is that these patients are nearly universally steroid resistant, and...
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RE: Nephrotic range proteinuria, steroid resistant FSGS ? Genetic, steroid treatment cessation 7 hours ago
Update : I started weaning prednisone slowly and he is on the last couple of weeks of prednisone 10mg. Proteinuria plateaued around 4 g but albumin...
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RE: Post-partum HELLP v. aHUS 8 hours ago
Sorry, I might have missed it but I did not see if schistocytes are present. Of course, lack of schistocytes does not mean it is not TMA. Two studi...
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RE: IgA Vasculitis in an adult 8 hours ago
The diagnisis of IgA V is based on both clinical and histopathological finding, such as a leucocytoclastic cutaneous vasculitus, arthralgias or abd...
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RE: Post-partum HELLP v. aHUS 8 hours ago
@Richard Smith @Carla Nester Dear Carla and Richard. Almost a decade has elapsed since you questioned the clinical utility of the MAC assay (Am J...
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RE: Post-partum HELLP v. aHUS 9 hours ago
Thank you Dr. Java for your prompt response. ------------------------------ Mario Rubin, M.D. Houston TX (000) 000-0000 -------------------------...
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RE: Post-partum HELLP v. aHUS 9 hours ago
https://www.ajkd.org/article/S0272-6386(15)00498-9/fulltext https://www.mayoclinicproceedings.org/article/S0025-6196(18)30663-3/fulltext Dr. Rub...
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RE: Hypertension urgency 9 hours ago
Like any paroxysmal disease, in which the episode frequency is difficult to predict, prevention is key, but poorly understood. If the BP is entirel...
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RE: Post-partum HELLP v. aHUS 9 hours ago
@Prem Chandran Can you please share the published key data on the membrane attack complex assays to guide the use of eculizumab? Thank you ----...
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RE: Post-partum HELLP v. aHUS 9 hours ago
@Anuja Java Can you please share the published key data on the clinical utility of the membrane attack complex assays? Thank you --------------...
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RE: Hypertension urgency 9 hours ago
I think you need to confirm HTN by ABPM or HBPM. After long term follow up of these patient with high office BP (WCH) and hypotension on ER oral an...
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RE: Post-partum HELLP v. aHUS 10 hours ago
With respect, I have to disagree. C5b-9 assay is the closest that the complement chemists have to offer to decide on whether or not the patient is ...
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RE: Post-partum HELLP v. aHUS 10 hours ago
I would not recommend deciding Ecu used based on the sC5b-9 assay. sC5b-9 levels by themselves are not reliable. Infact, sC5b-9 levels can be highe...
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RE: Post-partum HELLP v. aHUS 10 hours ago
I would recommend sending blood for a C3b-9 assay. I have no conflict of interest but Mayo labs have the shortest turnaround time. If the test is p...
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RE: Hypertension urgency 11 hours ago
Thank you for your inputs. Any recommendation for further management? Is it safe to keep potential hypertensive without medication? ---------...
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IgA Vasculitis in an adult 11 hours ago
I have a gentleman who is 59 YO who presented with RPGN clinically. Work up as outlined below. Diagnostic work up so far: #Lupus panel (June...
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RE: Hypertension urgency 11 hours ago
I assume that both of them were young because i saw many cases like this with the vast majority were prove to have no HTN by both ABPM and 1 week t...
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RE: Hypertension urgency 12 hours ago
As Dr Glassock suggested, exogeneous substances are number 1 suspects especially those that can cause sudden rises in BP. Any objective testing for...
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RE: proteinuria. ? timing of biopsy. 16 hours ago
One remaining unexplained issue is the disparity in kidney size. . Renal ultrasound can be notoriously problematical for determining kidnet size in...
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RE: proteinuria. ? timing of biopsy. 22 hours ago
Thanks. Possible that one APO1 high risk allele might be implicated as a second "hit" for FSFS in severe nephron under-endowment, tgat is almost ce...
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RE: proteinuria. ? timing of biopsy. 1 day ago
G1 only , one risk Allel. CUBN is heterzygous. ------------------------------ Khaldoun Soudan MD alexandria LA ------------------------------
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RE: Hypertension urgency 1 day ago
I guess these cases meet the "definition" of Pseudopheochromocytoma , a very vague (and rare) diagnosis, at best. Is it listed in ICD 10? -----...
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RE: Hypertension urgency 1 day ago
Thank you for your replies. Both of the patients denied having any drug intake, they were not on regular medications. They denied consuming any ove...
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RE: Nephrotic Syndrome with PIGN Picture 1 day ago
I don't know of any evidence that Cyclophosphamide , RTX or PLEX is effective and safe in cases like your patient. But lack of evidence is not equi...
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RE: Nephrotic Syndrome with PIGN Picture 1 day ago
C3NeF and anti FB & FH auto-antibodies are not available in the local laboratories, they should be sent abroad. I don't think she can afford it. C...
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RE: Hypertension urgency 1 day ago
Is the patient orthostatic? Pheos are often orthostatic from volume depletion related to pressure natiruesis. See attached. -----------------...
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RE: Post-partum HELLP v. aHUS 1 day ago
From Dr Chang: Roger, Thanks for reaching out about that challenging post-partum pt. That sounds very concerning for (complement-mediated) atyp...
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RE: Post-partum HELLP v. aHUS 1 day ago
Hi Dr. Landry, I was alerted to this post by a colleague asking for me to respond since I have interest in TMA/aHUS with a genetics background. ...
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RE: Post-partum HELLP v. aHUS 1 day ago
@Anthony Chang (U of C nephro-pathologist) posits that many of these TMA syndromes are all congenital complement deficiency mediated and that there...
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RE: Post-partum HELLP v. aHUS 1 day ago
No signs of SLE or anti-phospholipid syndrome? Based on the information you have shared , I would be giving strong consideration to employing Eculi...
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Post-partum HELLP v. aHUS 1 day ago
Good morning. I appreciate the opinions of this audience regarding 39-year-old female currently 4 days status post urgent C-section with persistent...
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RE: Hypertension urgency 1 day ago
Great idea. If catecholamines and abdominal CT are unremarkable, then this "diagnosis" seems very reasonable. ------------------------------ R...
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RE: Nephrotic Syndrome with PIGN Picture 1 day ago
Initially, "C3 was slightly consumed." Dr. Youssef: Serial C3 levels? Is microhematuria persisting? I assume SCr/eGFR remain normal although prot...
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RE: proteinuria. ? timing of biopsy. 1 day ago
Interesting findings. Were two high risk APOL1 risk alleles ( G1, G2 ) present?Was the CUBN mutation homozygous or heterozygous? What was the plasm...
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RE: Hypertension urgency 1 day ago
Pseudopheochromocytoma? Please see following review: https://pubmed.ncbi.nlm.nih.gov/35000148/ ------------------------------ K.K. Venkat MD T...
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RE: Nephrotic Syndrome with PIGN Picture 1 day ago
Compatible with C3GN. Infection related GN, less lijely. You might do a C3NeF and an anti-Factor B and anti factor H.For now , therapy with MMF and...
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RE: Hypertension urgency 1 day ago
Any history of drug abuse (especially cocaine) in either case.? I assume that catecholamine studies were unremarkable and no adrenal or retroperito...
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RE: 17q12 deletion syndrome 1 day ago
work my way up to 30 mg/d slowly, following K. ------------------------------ Roger Rodby MD, FASN Professor of Medicine Rush University Medical ...
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Hypertension urgency 1 day ago
Hi I came across couple of cases wherein two patients were brought to the emergency units in two different times with complains of headache or fe...
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RE: Nephrotic Syndrome with PIGN Picture 1 day ago
To update you, this is the EM report. She has clinically worsened, still edematous and proteinuria 9 gm on predn. & MMF. -------------------------...
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RE: Adjunctive acetazolamide therapy for the treatment of Bartter syndrome 1 day ago
No deafness Pending genetic --------------------------------- Mohamed Mahmoud MBBS NEPHROLOGIST MOH Egypt 00965 51377736 --------------------...
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RE: 17q12 deletion syndrome 1 day ago
How high would you go on Amiloride dose? Thanks! ------------------------------ Khaldoun Soudan MD alexandria LA ------------------------------
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RE: proteinuria. ? timing of biopsy. 1 day ago
Update: Genetic testing was done and interstingly showed: 1- Positive APOL1 heterozygous risk Allel 2-autosomal recessive CUBN, associated wit...
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