RE: Case of SLN normal dsDNA high SSA/SSB 6 minutes ago

Renal biopsy was 1 year back --------------------------------- Alaa Nabih Abdalla nephrology fellow Egypt ---------------------------------

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RE: Case of SLN normal dsDNA high SSA/SSB 2 hours ago

The pathology does not suggest a TMA, but an evaluation for anti phospholipid antibody is reasonable . Just an opinion, -------------------------...

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RE: Re: kidney biopsy findings in a young lady 2 hours ago

What is the staining intensity of C3 and IgG. Any Paraffin IF done after Pronase digestion. ? ------------------------------ Richard Glassock MD,...

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RE: Re: kidney biopsy findings in a young lady 3 hours ago

What was impression of Histopathologist. There is not much proliferation in intact gloms but to me it seems it is Primary/Idiopathic Immune Complex...

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RE: Case of SLN normal dsDNA high SSA/SSB 4 hours ago

Any thrombocytopenia ?? TMA ..APS should be excluded --------------------------------- Alaa Nabih Abdalla nephrology fellow Egypt ---------------...

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Re: kidney biopsy findings in a young lady 5 hours ago

Hi everyone, I wanted to discuss this patient who was referred for advanced CKD 4 Young lady in her 20s with HTN since the beginning of this y...

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RE: Case of SLN normal dsDNA high SSA/SSB 7 hours ago

My impression of this case is that it is one dominated by SS manifestations, not SLE, and the dose of MMF tolerated is inadequate to prevent furthe...

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RE: primary Membranous nephropathy and HBV infection 8 hours ago

Thanks Dr Awais for the article, couldn't get access to full manuscript but found another publication from Chinese group supporting the idea that a...

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RE: primary Membranous nephropathy and HBV infection 17 hours ago

This case, and others like it, raise the intriguing question of whether HBV infection itself is a driver of the Autoimmune phenomenon of anti-PLA2R...

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Case of SLN normal dsDNA high SSA/SSB 16 hours ago

Im taking over a case of 74yo woman and hope to get some opinions from the community. Pt has a diagnosis on SLE since 1996 presented as rash and wa...

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RE: NELL-1 positive membranous 17 hours ago

Sorry, Dr. Glassock it was misplaced Mawya Shocair MD

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RE: NELL-1 positive membranous 17 hours ago

This post seems to bear no resemblance to the original (male) case in this thread. Is this post misplaced? I cannot respond to the question posed d...

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RE: NELL-1 positive membranous 19 hours ago

Have u tested for syphilis --------------------------------- Alaa Nabih Abdalla nephrology fellow Egypt ---------------------------------

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RE: primary Membranous nephropathy and HBV infection 21 hours ago

Thanks for the Reference. I cannot acess the full article. Did they assess "reactivation" of HBV by serial measurement of circulating HBV virions ?...

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RE: cystatin C gfr 21 hours ago

The answers to your question can be found in the paper by Bukabao JB, et al. Kidney Int 2019; 95:1181-1190. The prognostic utility of eGFR Cystatin...

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RE: cystatin C gfr 22 hours ago

Recent studies showed combining eGFRcys-creat may have better prognostic value than eGFRcyst or eGFRcreat alone,is there any racial effect on eGFR ...

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RE: primary Membranous nephropathy and HBV infection 22 hours ago

Seems no urgency for therpay but would take opinion of GI. The following article may be of help. Low risk of hepatitis B virus reactivation in me...

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RE: primary Membranous nephropathy and HBV infection 22 hours ago

Appreciate your feedback Dr Glassock , Will watch for spontaneous remission and keep the community updated. ------------------------------ Abdal...

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RE: FSGS Tip Variant 23 hours ago

Dr Mohamad, patient wanted to know how effective Ritux would be when I offered it to him. This followed discussion that one would be more certain a...

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RE: primary Membranous nephropathy and HBV infection 1 day ago

I think you have time to wait. Unfortunately, unlike HCV, it is very difficult to "cure" HBV with antiviral agents. The HBV can lurk in the liver i...

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RE: NELL-1 positive membranous 1 day ago

I am not aware of any strong data linking amphetamines or cannabis abuse to NELL1 MN, but I suppose that anything is possible, especially illicit H...

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RE: primary Membranous nephropathy and HBV infection 1 day ago

My only concern is that anti PLAR2R Ab level has been constantly above 200 ru/ml , otherwise kidney function is preserved and proteinuria < 4 g/24 ...

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RE: NELL-1 positive membranous 1 day ago

She had been on Colchicine almost all her life. She stopped it few months ago. Her baseline serum creatinine in July was 1.0.She came in with abdom...

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RE: Pregnancy in Transplant patients with aHUs and on complement inhibitors 1 day ago

Greetings Did she develop ESRD from an episode of aHUS prior to transplant? If so, that would worry me. That being said, people have used eculizu...

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RE: cystatin C gfr 1 day ago

The "improvement" in outcome prediction for eGFR-Cystatin C over eGFR-creatinine very likely has little to do with GFR itself, but ratherc is due t...

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RE: cystatin C gfr 1 day ago

Hi, I have no much experience with Cys based equations, but It's interesting what is mention in Kidney360 article about that in extremes situations...

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RE: FSGS Tip Variant 1 day ago

Thank you Dr. Nauman and congratulation on getting this patient into remission, great job! wonder why you restarted the steroids instead of just gi...

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RE: Tip variant FSGS 1 day ago

Very active maybe proteinuria will stabalize Has anyone had any luck with sglt2i and FSGS I haven't?I think they are less useful than ACEi/aRB bu...

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RE: Pregnancy in Transplant patients with aHUs and on complement inhibitors 1 day ago

Does she have pathologenic genetic variant ؟؟ Some variants have high risk of relapse others are low risk If no variant detected relapse are minma...

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RE: Tip variant FSGS 1 day ago

His mother may accept SGLT inhibitor --------------------------------- Alaa Nabih Abdalla nephrology fellow Egypt ------------------------------...

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RE: IgA With ANCA Positivity 1 day ago

Total glomeruli: 41 Global sclerosis: 13 Segmental sclerosis: 7 --------------------------------- Kinjal Gosalia MD Dix Hills NY (516) 504-5279...

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RE: IgA With ANCA Positivity 1 day ago

Albumin 3.9. No edema. So no nephrotic syndrome just nephrotic range proteinuria. BMI 39. It could be secondary FSGS from IgA or Obesity --------...

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RE: IgA With ANCA Positivity 1 day ago

No hydrazine, allopurinol, PTU, methimazole, IVDU --------------------------------- Kinjal Gosalia MD Dix Hills NY (516) 504-5279 --------------...

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RE: IgA With ANCA Positivity 1 day ago

SAlb level? How much edema? Is "50% glomerulosclerosis" global? How obese is she? If this is a primary podocytopathy would expect significant hypoa...

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RE: Tip variant FSGS 1 day ago

"Very active fit kid." Some of the fluctuation in proteinuria may be the effect of heavy physical activity increasing it. ---------------------...

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RE: Tip variant FSGS 1 day ago

Yes I would not treat now at what point would you treat? Nephrotic range probably too late but > 1gm albumin/cr and lower serum albumin thank...

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RE: Pregnancy in Transplant patients with aHUs and on complement inhibitors 1 day ago

Not much experience with Eculizumab or Ravulizumab in Pregancey Several reports of their use in PNH and Pregnacy and PNH indicate tgat it may be sa...

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RE: IgA With ANCA Positivity 1 day ago

I would treat with oral systemic prednisone just as you would with a primary Podocytopathy . I do not know what to make of the serology. Has the pa...

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RE: Tip variant FSGS 1 day ago

With these findings I would just follow the patient with repeat values about every 3 months. ------------------------------ Richard Glassock MD,...

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RE: Tip variant FSGS 1 day ago

Serum albumin is 4.4 and stable. UPCR 0.6, albumin/cr 338 mg/gm ------------------------------ Kevin Mitchell MD Nephrologist St. Luke?s Medical ...

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RE: IgA With ANCA Positivity 1 day ago

Thank you Dr. Glassock. Thant’s a great point. I’ll wait for the EM. Would you do do pulse and prednisone or localized such as Tarpeyo? ---------...

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RE: primary Membranous nephropathy and HBV infection 1 day ago

I would wait several moths after successful therapy of HBV with Entecavir . Follow anti-PLA2R antibody levels, there is a fairly good chance for a ...

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RE: Tip variant FSGS 1 day ago

What is the serum albumin level? No indication for repeat kidney biopsy. You might want to consider RTX for relapsing steroid sensitive MCD/FSGS. ...

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RE: IgA With ANCA Positivity 1 day ago

Do you have EM to further characterize the S1 lesion-e.g. - is a diffuse Podocytopathy present. If so, oral systemic steroids are indicted, in my o...

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RE: APOL-1 mediated kidney disease 1 day ago

Amplitude Study by Vertex pharma. Multinational study. Sure they are recruiting in your area. ------------------------------ Anurag Tikaria MD, ...

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Pregnancy in Transplant patients with aHUs and on complement inhibitors 1 day ago

Good Afternoon, I looking to hear some experiences any of you have had in transplant patients who have a dx of aHUS and want to become pregnant....

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IgA With ANCA Positivity 1 day ago

I have a 50-year-old male with past medical history of hypertension, obesity and prediabetes. Non smoker. Only on Lovaza and amlodipine as meds. Cr...

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RE: Tip variant FSGS 1 day ago

I did not mean to re biopsy but wait until >1gm to treat with CNI ------------------------------ Kevin Mitchell MD Nephrologist St. Luke?s Medica...

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RE: primary Membranous nephropathy and HBV infection 1 day ago

I would like to update regarding my patient with MN PLAR2Ab + ve and active HBV infectio . we started him on entecavir 2 months back and HBV DNA is...

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RE: Tip variant FSGS 1 day ago

I would be hesitant to biopsy to convince mother, nor do I think doing it at a relapse would impact management. What has worked for me (sometimes) ...

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