Abstract: FR-PO941
Demographics and Trends of Mortality Due to Nephritic Syndrome in the United States, 1999-2020
Session Information
- Glomerular Diseases: Potpourri
October 25, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Shah, Badar U Din, Geisinger Health, Danville, Pennsylvania, United States
- Shaukat, Muhammad Talha, King Edward Medical University, Lahore, Pakistan
- Rehman, Wania, King Edward Medical University, Lahore, Pakistan
- Hayat, Malik Saad, King Edward Medical University, Lahore, Pakistan
- Shahid, Fatima, King Edward Medical University, Lahore, Pakistan
- Rehman, Aqeeb Ur, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, United States
- Mohsin, Aleenah, Brown University, Providence, Rhode Island, United States
Background
The mortality rate associated with nephritic syndrome in the US is on the rise. We analyze mortality trends from 1999 to 2020 using age-adjusted mortality rates (AAMR) to identify disparities among different demographic groups.
Methods
Data was extracted from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiological Research (CDC WONDER) database from 1999 to 2020. Age-adjusted mortality rate (AAMR) per 100,000 individuals and annual percent changes (APC) with 95% Confidence Intervals (CI) were calculated using Joinpoint regression analysis for different epidemiological cohorts stratified by gender, race, and locale.
Results
From 1999-2020, 120103 nephritic syndrome-related deaths were documented. APC of 89.21 from 2003-2007, 26.75 from 2007-2010, and 14.2 from 2013-2020 indicate an increasing trend in AAMR from 1999-2020. However, there was a notable drop in nephritis associated mortality between 2010 and 2013 (APC= -62.73). Certain groups experienced consistently higher death rates, including African Americans (average annual percentage change (AAPC):2.72, 95% CI:-3.8 to 9.7), males (AAPC:4.04, 95% CI:-0.9 to9.2), individuals aged 85 and older. The Midwest region had the highest mortality rates (AAMR:1.8), followed by the South and West (AAMR:1.7) and the Northeast (AAMR 1.3). Specific states with high mortality rates included Tennessee, South Carolina, Minnesota, Wisconsin and Oregon. There was no significant difference in mortality rates between metropolitan (AAPC:3.62) and non-metropolitan areas (AAPC: 3.90).
Conclusion
The rise in nephritic syndrome-related mortality from 1999 to 2020 is concerning and underscores the need for focused research and targeted interventions. Continued efforts are essential to ensure equitable access to effective treatments and improve patient outcomes across all affected demographic groups.
Mortality trends of nephritic syndrome across different races