Abstract: FR-PO920
The Spectrum of Biopsy-Proven Kidney Disease in People Living with HIV in Tertiary-Care Centers in Mexico City
Session Information
- Glomerular Diseases: Potpourri
October 25, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Caballero-Islas, Adrián Esteban, Instituto Nacional de Enfermedades Respiratorias, Mexico, Mexico City, Mexico
- Ascencion Lopez, Carlos, Instituto Nacional de Enfermedades Respiratorias, Mexico, Mexico City, Mexico
- Pacchiano, Lillana, Instituto Nacional de Enfermedades Respiratorias, Mexico, Mexico City, Mexico
- Mendoza, Arnulfo, Instituto Nacional de Enfermedades Respiratorias, Mexico, Mexico City, Mexico
- Leon Ortiz, Jose Antonio, Instituto Nacional de Enfermedades Respiratorias, Mexico, Mexico City, Mexico
- Nava, Marcos García, Instituto Nacional de Enfermedades Respiratorias, Mexico, Mexico City, Mexico
- Vasquez Jiménez, Enzo Christopher, Hospital Juarez de Mexico, Mexico City, Mexico City, Mexico
- Casas-Aparicio, Gustavo Alejandro, Instituto Nacional de Enfermedades Respiratorias, Mexico, Mexico City, Mexico
Background
People living with HIV are prone to kidney disease as a result of multiple mechanisms; those directly related to the virus, drug effects, and related infections. Kidney biopsy allows a more accurate approach to kidney disease in this setting.
Methods
A retrospective study that included all HIV-positive patients with a clinical indication for a kidney biopsy was performed between January 2018 and May 2024 at 3 centers in Mexico City. Data was collected at the time of the biopsy
Results
Eighteen kidney biopsies were included. The mean age was of 44.7 years and the median time from diagnosis to biopsy was 92 months(4.5-128).The most common indication was nephrotic syndrome(61%).Glomerular lesions were the most frequent finding(83%) and immune complex-mediated glomerular disease the most prevalent lesion. Among diabetic patients, 60% presented lesions not related to diabetes.
Conclusion
In our study, immune complex-mediated glomerular disease was the most common diagnosis. In individuals with diabetes, 60% had a kidney disease not related to diabetes, emphasizing the importance of performing biopsies to improve outcomes.
| Age, yrs(mean±SD) | 44.7±13.6 |
| Male,n(%) | 16(89) |
| Serum creatinine,mg/dL(median, IQR) | 1.76(1.18-2.34) |
| eGFR, mL/min/1.73 m2 | 44.9(34.1-71) |
| Serum albumin,g/dL | 2.21(0.97-4.01) |
| Proteinuria, g/d or g/g | 3.9(2.1-7.6) |
| CD4 count, cells/mL | 315(116-653) |
| Diabetes,n (%) | 5(28) |
| Hypertension | 7(39) |
| Hepatitis B | 2(11) |
| Hepatitis C | 2(11) |
| On Antiretroviral therapy | 17(94) |
| CD4 count > 200 cells/mL | 11(61) |
| Viral load < 40 copies | 11(61) |