Abstract: TH-PO976
Health Trajectories of Adults with ESKD and Obesity Who Are Trying to Lose Weight
Session Information
- Physical Activity and Lifestyle in Kidney Diseases
October 24, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Stott, Dahlia, Drexel University, Philadelphia, Pennsylvania, United States
- Gunen, Bengucan, Drexel University, Philadelphia, Pennsylvania, United States
- Chien, Stephen, Drexel University, Philadelphia, Pennsylvania, United States
- Milliron, Brandy-Joe, Drexel University, Philadelphia, Pennsylvania, United States
- Klassen, Ann Carroll, Drexel University, Philadelphia, Pennsylvania, United States
- Robinson, Lucy, Drexel University, Philadelphia, Pennsylvania, United States
- Cobb, Jason, Emory University, Atlanta, Georgia, United States
- Doyle, Alden Michael, University of Virginia, Charlottesville, Virginia, United States
- Harhay, Meera Nair, Drexel University, Philadelphia, Pennsylvania, United States
Background
Adults with ESKD and obesity (i.e., body mass index ≥30 kg/m2) have reported numerous barriers to healthy weight loss, limiting access to transplantation. Weight loss in ESKD patients may also indicate frailty or sarcopenia. Knowledge gaps persist about predictors of healthy weight loss in adults with ESKD and obesity.
Methods
In our longitudinal cohort study, we are assessing predictors of weight, body composition (using bioimpedance spectroscopy), anthropometry, and functional trajectories among adults with ESKD and obesity who are trying to lose weight. In this preliminary analysis, we compare dietary quality, health literacy, and 3-month changes in fat free mass, waist circumference, and physical function of participants who did and did not achieve weight loss using t-tests and Mann-Whitney U tests, as appropriate.
Results
Among 34 participants with longitudinal data to date, 41% lost weight at 3 months (mean loss 2 kg, SD 1.74 kg). Mean participant age was 57 years; 47% were female, and 94% identified as non-Hispanic Black. No participants were taking weight loss medication at baseline. Participant characteristics, dietary intake, and health literacy were similar between those with and without weight loss. Participants who lost weight were more likely to lose waist circumference but had similar changes in fat free mass and physical function as those without weight loss (Table).
Conclusion
Less than half of participants achieved desired weight loss at 3 months. Those who lost weight had similar baseline dietary quality and health literacy but were more likely to lose waist circumference than those who did not lose weight. Fat free mass and functional status changes were observed with and without weight loss.
| Participants with weight loss (n=14) | Participants without weight loss (n=20) | ||||
| Mean | Standard Deviation | Mean | Standard Deviation | p | |
| Baseline age | 56.64 | 13.98 | 57.75 | 11.30 | .800 |
| Baseline body mass index (kg/m2) | 36.47 | 5.35 | 37.96 | 7.51 | .717 |
| Baseline calories/day | 1369.86 | 246.14 | 1685.11 | 695.17 | .323 |
| Baseline protein/day, grams | 63.27 | 13.59 | 75.13 | 24.16 | .107 |
| Baseline dietary quality (0-100) | 48.41 | 8.19 | 48.92 | 7.74 | .854 |
| Baseline health literacy (0-18) | 15.50 | 3.59 | 14.55 | 4.97 | .500 |
| 3-month fat free mass change, kg | .38 | 4.65 | 5.03 | 6.55 | .156 |
| 3-month waist circumference change, in | -.66 | 2.47 | 2.22 | 2.30 | .001 |
| 3-month timed gait change, sec | 0.00 | 1.03 | -.06 | 1.61 | .911 |
| 3-month grip strength change, kg | -.88 | 9.12 | -.91 | 7.59 | .959 |
Funding
- NIDDK Support